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PubMed:12820722 JSONTXT 39 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-93 Sentence denotes Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac:
T1 0-93 Sentence denotes Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac:
TextSentencer_T2 94-147 Sentence denotes GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA.
T2 94-147 Sentence denotes GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA.
TextSentencer_T3 148-349 Sentence denotes Sialyl-Tn antigen (STn) is a cancer associated carbohydrate antigen over-expressed in several cancers including breast cancer, and currently associated with more aggressive diseases and poor prognosis.
T3 148-349 Sentence denotes Sialyl-Tn antigen (STn) is a cancer associated carbohydrate antigen over-expressed in several cancers including breast cancer, and currently associated with more aggressive diseases and poor prognosis.
TextSentencer_T4 350-458 Sentence denotes However, the commonly used breast cancer cell lines (MDA-MB-231, T47-D and MCF7) do not express STn antigen.
T4 350-458 Sentence denotes However, the commonly used breast cancer cell lines (MDA-MB-231, T47-D and MCF7) do not express STn antigen.
TextSentencer_T5 459-586 Sentence denotes The key step in the biosynthesis of STn is the transfer of a sialic acid residue in alpha2,6-linkage to GalNAc alpha-O-Ser/Thr.
T5 459-586 Sentence denotes The key step in the biosynthesis of STn is the transfer of a sialic acid residue in alpha2,6-linkage to GalNAc alpha-O-Ser/Thr.
TextSentencer_T6 587-684 Sentence denotes This reaction is mainly catalyzed by a CMP-Neu5Ac GalNAc alpha2,6-sialyltransferase: ST6GalNAc I.
T6 587-684 Sentence denotes This reaction is mainly catalyzed by a CMP-Neu5Ac GalNAc alpha2,6-sialyltransferase: ST6GalNAc I.
TextSentencer_T7 685-826 Sentence denotes In order to generate STn-positive breast cancer cells, we have cloned a cDNA encoding the full-length human ST6GalNAc I from HT-29-MTX cells.
T7 685-826 Sentence denotes In order to generate STn-positive breast cancer cells, we have cloned a cDNA encoding the full-length human ST6GalNAc I from HT-29-MTX cells.
TextSentencer_T8 827-970 Sentence denotes The stable transfection of MDA-MB-231 with an expression vector encoding ST6GalNAc I induces the expression of STn antigen at the cell surface.
T8 827-970 Sentence denotes The stable transfection of MDA-MB-231 with an expression vector encoding ST6GalNAc I induces the expression of STn antigen at the cell surface.
TextSentencer_T9 971-1184 Sentence denotes The expression of STn short cuts the initial O-glycosylation pattern of these cell lines, by competing with the Core-1 beta1,3-galactosyltransferase, the first enzyme involved in the elongation of O-glycan chains.
T9 971-1184 Sentence denotes The expression of STn short cuts the initial O-glycosylation pattern of these cell lines, by competing with the Core-1 beta1,3-galactosyltransferase, the first enzyme involved in the elongation of O-glycan chains.
TextSentencer_T10 1185-1326 Sentence denotes Moreover, we show that STn expression is associated with morphological changes, decreased growth and increased migration of MDA-MB-231 cells.
T10 1185-1326 Sentence denotes Moreover, we show that STn expression is associated with morphological changes, decreased growth and increased migration of MDA-MB-231 cells.