| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-103 |
Sentence |
denotes |
Interspecies contamination of the KM3 cell line: implications for CD63 function in melanoma metastasis. |
| T1 |
0-103 |
Sentence |
denotes |
Interspecies contamination of the KM3 cell line: implications for CD63 function in melanoma metastasis. |
| TextSentencer_T2 |
104-312 |
Sentence |
denotes |
CD63 is a member of the tetraspanin superfamily of membrane glycoproteins that has been hypothesised to provide a structural network in the organisation of large multimolecular microdomains at cell membranes. |
| T2 |
104-312 |
Sentence |
denotes |
CD63 is a member of the tetraspanin superfamily of membrane glycoproteins that has been hypothesised to provide a structural network in the organisation of large multimolecular microdomains at cell membranes. |
| TextSentencer_T3 |
313-491 |
Sentence |
denotes |
Detailed analyses of the role of CD63 in these complexes through mutagenic studies have been limited, however, by the ubiquitous cellular expression of CD63 in vivo and in vitro. |
| T3 |
313-491 |
Sentence |
denotes |
Detailed analyses of the role of CD63 in these complexes through mutagenic studies have been limited, however, by the ubiquitous cellular expression of CD63 in vivo and in vitro. |
| TextSentencer_T4 |
492-639 |
Sentence |
denotes |
In an attempt to define CD63-null cell lines, we have analysed the expression of CD63 and other tetraspanins on a panel of human cancer cell lines. |
| T4 |
492-639 |
Sentence |
denotes |
In an attempt to define CD63-null cell lines, we have analysed the expression of CD63 and other tetraspanins on a panel of human cancer cell lines. |
| TextSentencer_T5 |
640-749 |
Sentence |
denotes |
Similar expression patterns were seen between cell lines from melanomas, breast cancers and prostate cancers. |
| T5 |
640-749 |
Sentence |
denotes |
Similar expression patterns were seen between cell lines from melanomas, breast cancers and prostate cancers. |
| TextSentencer_T6 |
750-901 |
Sentence |
denotes |
The melanoma cell line KM3, however, described previously as a CD63-null human cell line, was found to express none of the 7 human tetraspanins tested. |
| T6 |
750-901 |
Sentence |
denotes |
The melanoma cell line KM3, however, described previously as a CD63-null human cell line, was found to express none of the 7 human tetraspanins tested. |
| TextSentencer_T7 |
902-1001 |
Sentence |
denotes |
KM3 was identified definitively as a rat cell line by analysis of karyotype and antigen expression. |
| T7 |
902-1001 |
Sentence |
denotes |
KM3 was identified definitively as a rat cell line by analysis of karyotype and antigen expression. |
| TextSentencer_T8 |
1002-1062 |
Sentence |
denotes |
Notably, KM3 was found to express the rat homologue of CD63. |
| T8 |
1002-1062 |
Sentence |
denotes |
Notably, KM3 was found to express the rat homologue of CD63. |
| TextSentencer_T9 |
1063-1275 |
Sentence |
denotes |
Conclusions concerning the function of human CD63 drawn from studies using KM3 cells therefore require re-evaluation as does the frequently cited hypothesis that CD63 expression is linked to melanoma progression. |
| T9 |
1063-1275 |
Sentence |
denotes |
Conclusions concerning the function of human CD63 drawn from studies using KM3 cells therefore require re-evaluation as does the frequently cited hypothesis that CD63 expression is linked to melanoma progression. |
| TextSentencer_T10 |
1276-1422 |
Sentence |
denotes |
As KM3 is the only cell line thus far identified as CD63 negative, these results highlight the necessity for the production of a CD63 null system. |
| T10 |
1276-1422 |
Sentence |
denotes |
As KM3 is the only cell line thus far identified as CD63 negative, these results highlight the necessity for the production of a CD63 null system. |