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PubMed:12730195 JSONTXT 19 Projects

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Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination.
T2 126-317 Sentence denotes A putative oncogene bcl-3 was originally identified and cloned at the breakpoint in the recurring chromosome translocation t(14;19) found in some cases of B cell chronic lymphocytic leukemia.
T3 318-503 Sentence denotes Studies of bcl-3-deficient mice demonstrated a critical role for bcl-3 in the development of a normal immune response and the formation of germinal centers in secondary lymphoid organs.
T4 504-623 Sentence denotes However, the molecular mechanism that underlies B cell leukemogenesis and the knockout mouse phenotype remains unclear.
T5 624-798 Sentence denotes Here we have identified and characterized BCL-3-binding protein (B3BP) as a protein interacting specifically with the bcl-3 gene product (BCL-3) by a yeast two-hybrid screen.
T6 799-894 Sentence denotes We found that B3BP associates with not only BCL-3 but also p300/CBP histone acetyltransferases.
T7 895-1017 Sentence denotes The N-terminal region of B3BP that contains the ATP-binding site is important for the interaction with BCL-3 and p300/CBP.
T8 1018-1264 Sentence denotes Homology searches indicate that the ATP-binding region of B3BP, which contains a typical Walker-type ATP-binding P-loop, most resembles that of 2',3'-cyclic nucleotide 3'-phosphodiesterase of mammals and polynucleotide kinase of T4 bacteriophage.
T9 1265-1331 Sentence denotes In fact B3BP shows intrinsic ATP binding and hydrolyzing activity.
T10 1332-1401 Sentence denotes Furthermore, we demonstrated that B3BP is a 5'-polynucleotide kinase.
T11 1402-1599 Sentence denotes We also found a small MutS-related domain, which is thought to be involved in the DNA repair or recombination reaction, in the C-terminal region of B3BP, and it shows nicking endonuclease activity.
T12 1600-1762 Sentence denotes These observations might help to gain new insights into the function of BCL-3 and p300/CBP, especially the coupling of transcription with repair or recombination.