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PubMed:12649279 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta.
T2 132-286 Sentence denotes Mutations in the human tau gene leading to aberrant splicing have been identified in FTDP-17, an autosomal dominant hereditary neurodegenerative disorder.
T3 287-380 Sentence denotes Molecular mechanisms by which such mutations cause tau aberrant splicing were not understood.
T4 381-458 Sentence denotes We characterized two mutations in exon 10 of the tau gene, N279K and Del280K.
T5 459-535 Sentence denotes Our results revealed an exonic splicing enhancer element located in exon 10.
T6 536-626 Sentence denotes The activity of this AG-rich splicing enhancer was altered by N279K and Del280K mutations.
T7 627-695 Sentence denotes This exonic enhancer element interacts with human Tra2 beta protein.
T8 696-841 Sentence denotes The interaction between Tra2 beta and the exonic splicing enhancer correlates with the activity of this enhancer element in stimulating splicing.
T9 842-1034 Sentence denotes Biochemical studies including in vitro splicing and RNA interference experiments in transfected cells support a role for Tra2 beta protein in regulating alternative splicing of human tau gene.
T10 1035-1269 Sentence denotes Our results implicate the human tau gene as a target gene for the alternative splicing regulator Tra2 beta, suggesting that Tra2 beta may play a role in aberrant tau exon 10 alternative splicing and in the pathogenesis of tauopathies.