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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-128 Sentence denotes Characterization by NMR and molecular modeling of the binding of polyisoprenols and polyisoprenyl recognition sequence peptides:
T1 0-128 Sentence denotes Characterization by NMR and molecular modeling of the binding of polyisoprenols and polyisoprenyl recognition sequence peptides:
T1 0-128 Sentence denotes Characterization by NMR and molecular modeling of the binding of polyisoprenols and polyisoprenyl recognition sequence peptides:
TextSentencer_T2 129-198 Sentence denotes 3D structure of the complexes reveals sites of specific interactions.
T2 129-198 Sentence denotes 3D structure of the complexes reveals sites of specific interactions.
T2 129-198 Sentence denotes 3D structure of the complexes reveals sites of specific interactions.
TextSentencer_T3 199-498 Sentence denotes The objective of these studies was to test the hypothesis that proteins that contain potential polyisoprenyl recognition sequences (PIRSs) in their transmembrane-spanning domain can bind to the polyisoprenyl (PI) glycosyl carrier lipids undecaprenyl phosphate (C55-P) and dolichyl phosphate (C95-P).
T3 199-498 Sentence denotes The objective of these studies was to test the hypothesis that proteins that contain potential polyisoprenyl recognition sequences (PIRSs) in their transmembrane-spanning domain can bind to the polyisoprenyl (PI) glycosyl carrier lipids undecaprenyl phosphate (C55-P) and dolichyl phosphate (C95-P).
T3 199-498 Sentence denotes The objective of these studies was to test the hypothesis that proteins that contain potential polyisoprenyl recognition sequences (PIRSs) in their transmembrane-spanning domain can bind to the polyisoprenyl (PI) glycosyl carrier lipids undecaprenyl phosphate (C55-P) and dolichyl phosphate (C95-P).
TextSentencer_T4 499-656 Sentence denotes A number of prokaryotic and eukaryotic glycosyltransferases that utilize PI coenzymes contain a conserved PIRS postulated to be the active PI binding domain.
T4 499-656 Sentence denotes A number of prokaryotic and eukaryotic glycosyltransferases that utilize PI coenzymes contain a conserved PIRS postulated to be the active PI binding domain.
T4 499-656 Sentence denotes A number of prokaryotic and eukaryotic glycosyltransferases that utilize PI coenzymes contain a conserved PIRS postulated to be the active PI binding domain.
TextSentencer_T5 657-809 Sentence denotes To study this problem, we first determined the 3D structure of a PIRS peptide, NeuE, by homonuclear 2D 1H-nuclear magnetic resonance (NMR) spectroscopy.
T5 657-809 Sentence denotes To study this problem, we first determined the 3D structure of a PIRS peptide, NeuE, by homonuclear 2D 1H-nuclear magnetic resonance (NMR) spectroscopy.
T5 657-809 Sentence denotes To study this problem, we first determined the 3D structure of a PIRS peptide, NeuE, by homonuclear 2D 1H-nuclear magnetic resonance (NMR) spectroscopy.
TextSentencer_T6 810-1043 Sentence denotes Experimentally generated distance constraints derived from nuclear Overhauser enhancement and torsion angle constraints derived from coupling constants were used for restrained molecular dynamics and energy minimization calculations.
T6 810-1043 Sentence denotes Experimentally generated distance constraints derived from nuclear Overhauser enhancement and torsion angle constraints derived from coupling constants were used for restrained molecular dynamics and energy minimization calculations.
T6 810-1043 Sentence denotes Experimentally generated distance constraints derived from nuclear Overhauser enhancement and torsion angle constraints derived from coupling constants were used for restrained molecular dynamics and energy minimization calculations.
TextSentencer_T7 1044-1171 Sentence denotes Molecular models of the NeuE peptide were built based on calculations of energy minimization using the DGII program NMRchitect.
T7 1044-1171 Sentence denotes Molecular models of the NeuE peptide were built based on calculations of energy minimization using the DGII program NMRchitect.
T7 1044-1171 Sentence denotes Molecular models of the NeuE peptide were built based on calculations of energy minimization using the DGII program NMRchitect.
TextSentencer_T8 1172-1437 Sentence denotes 3D models of dolichol (C95) and C95-P were built based on our 2D 1H-NMR nuclear Overhauser enhancement spectroscopy (NOESY) results and refined by energy minimization with respect to all atoms using the AMBER (assisted modeling with energy refinements) force field.
T8 1172-1437 Sentence denotes 3D models of dolichol (C95) and C95-P were built based on our 2D 1H-NMR nuclear Overhauser enhancement spectroscopy (NOESY) results and refined by energy minimization with respect to all atoms using the AMBER (assisted modeling with energy refinements) force field.
T8 1172-1437 Sentence denotes 3D models of dolichol (C95) and C95-P were built based on our 2D 1H-NMR nuclear Overhauser enhancement spectroscopy (NOESY) results and refined by energy minimization with respect to all atoms using the AMBER (assisted modeling with energy refinements) force field.
TextSentencer_T9 1438-1619 Sentence denotes Our energy minimization studies were carried out on a conformational model of dolichol that was originally derived from small-angle X-ray scattering and molecular mechanics methods.
T9 1438-1619 Sentence denotes Our energy minimization studies were carried out on a conformational model of dolichol that was originally derived from small-angle X-ray scattering and molecular mechanics methods.
T9 1438-1619 Sentence denotes Our energy minimization studies were carried out on a conformational model of dolichol that was originally derived from small-angle X-ray scattering and molecular mechanics methods.
TextSentencer_T10 1620-1781 Sentence denotes These results revealed that the PIs are conformationally nearly identical tripartite molecules, with their three domains arranged in a coiled, helical structure.
T10 1620-1781 Sentence denotes These results revealed that the PIs are conformationally nearly identical tripartite molecules, with their three domains arranged in a coiled, helical structure.
T10 1620-1781 Sentence denotes These results revealed that the PIs are conformationally nearly identical tripartite molecules, with their three domains arranged in a coiled, helical structure.
TextSentencer_T11 1782-2050 Sentence denotes Analyses of the intermolecular cross-peaks in the 2D NOESY spectra of PIRS peptides in the presence of PIs confirmed a highly specific interaction and identified key contact amino acids in the NeuE peptide that constituted a binding motif for interacting with the PIs.
T11 1782-2050 Sentence denotes Analyses of the intermolecular cross-peaks in the 2D NOESY spectra of PIRS peptides in the presence of PIs confirmed a highly specific interaction and identified key contact amino acids in the NeuE peptide that constituted a binding motif for interacting with the PIs.
T11 1782-2050 Sentence denotes Analyses of the intermolecular cross-peaks in the 2D NOESY spectra of PIRS peptides in the presence of PIs confirmed a highly specific interaction and identified key contact amino acids in the NeuE peptide that constituted a binding motif for interacting with the PIs.
TextSentencer_T12 2051-2176 Sentence denotes These studies also showed that subtle conformational changes occurred within both the PIs and the NeuE peptide after binding.
T12 2051-2176 Sentence denotes These studies also showed that subtle conformational changes occurred within both the PIs and the NeuE peptide after binding.
T12 2051-2176 Sentence denotes These studies also showed that subtle conformational changes occurred within both the PIs and the NeuE peptide after binding.
TextSentencer_T13 2177-2288 Sentence denotes 3D structures of the resulting molecular complexes revealed that each PI could bind more than one PIRS peptide.
T13 2177-2288 Sentence denotes 3D structures of the resulting molecular complexes revealed that each PI could bind more than one PIRS peptide.
T13 2177-2288 Sentence denotes 3D structures of the resulting molecular complexes revealed that each PI could bind more than one PIRS peptide.
TextSentencer_T14 2289-2504 Sentence denotes These studies thus represent the first evidence for a direct physical interaction between specific contact amino acids in the PIRS peptides and the PIs and supports the hypothesis of a bifunctional role for the PIs.
T14 2289-2504 Sentence denotes These studies thus represent the first evidence for a direct physical interaction between specific contact amino acids in the PIRS peptides and the PIs and supports the hypothesis of a bifunctional role for the PIs.
T14 2289-2504 Sentence denotes These studies thus represent the first evidence for a direct physical interaction between specific contact amino acids in the PIRS peptides and the PIs and supports the hypothesis of a bifunctional role for the PIs.
TextSentencer_T15 2505-2759 Sentence denotes The central idea is that these superlipids may serve as a structural scaffold to organize and stabilize in functional domains PIRS-containing proteins within multiglycosyltransferase complexes that participate in biosynthetic and translocation processes.
T15 2505-2759 Sentence denotes The central idea is that these superlipids may serve as a structural scaffold to organize and stabilize in functional domains PIRS-containing proteins within multiglycosyltransferase complexes that participate in biosynthetic and translocation processes.
T15 2505-2759 Sentence denotes The central idea is that these superlipids may serve as a structural scaffold to organize and stabilize in functional domains PIRS-containing proteins within multiglycosyltransferase complexes that participate in biosynthetic and translocation processes.