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TextSentencer_T1 0-127 Sentence denotes A biochemical and pharmacological comparison of enzyme replacement therapies for the glycolipid storage disorder Fabry disease.
T1 0-127 Sentence denotes A biochemical and pharmacological comparison of enzyme replacement therapies for the glycolipid storage disorder Fabry disease.
T1 0-127 Sentence denotes A biochemical and pharmacological comparison of enzyme replacement therapies for the glycolipid storage disorder Fabry disease.
TextSentencer_T2 128-233 Sentence denotes Fabry disease is a lysosomal storage disease arising from deficiency of the enzyme alpha-galactosidase A.
T2 128-233 Sentence denotes Fabry disease is a lysosomal storage disease arising from deficiency of the enzyme alpha-galactosidase A.
T2 128-411 Sentence denotes Fabry disease is a lysosomal storage disease arising from deficiency of the enzyme alpha-galactosidase A. Two recombinant protein therapeutics, Fabrazyme (agalsidase beta) and Replagal (agalsidase alfa), have been approved in Europe as enzyme replacement therapies for Fabry disease.
TextSentencer_T3 234-411 Sentence denotes Two recombinant protein therapeutics, Fabrazyme (agalsidase beta) and Replagal (agalsidase alfa), have been approved in Europe as enzyme replacement therapies for Fabry disease.
T3 234-411 Sentence denotes Two recombinant protein therapeutics, Fabrazyme (agalsidase beta) and Replagal (agalsidase alfa), have been approved in Europe as enzyme replacement therapies for Fabry disease.
TextSentencer_T4 412-597 Sentence denotes Both contain the same human enzyme, alpha-galactosidase A, but they are produced using different protein expression systems and have been approved for administration at different doses.
T3 412-597 Sentence denotes Both contain the same human enzyme, alpha-galactosidase A, but they are produced using different protein expression systems and have been approved for administration at different doses.
T4 412-597 Sentence denotes Both contain the same human enzyme, alpha-galactosidase A, but they are produced using different protein expression systems and have been approved for administration at different doses.
TextSentencer_T5 598-809 Sentence denotes To determine if there is recognizable biochemical basis for the different doses, we performed a comparison of the two drugs, focusing on factors that are likely to influence biological activity and availability.
T4 598-809 Sentence denotes To determine if there is recognizable biochemical basis for the different doses, we performed a comparison of the two drugs, focusing on factors that are likely to influence biological activity and availability.
T5 598-809 Sentence denotes To determine if there is recognizable biochemical basis for the different doses, we performed a comparison of the two drugs, focusing on factors that are likely to influence biological activity and availability.
TextSentencer_T6 810-924 Sentence denotes The two drugs have similar glycosylation, both in the type and location of the oligosaccharide structures present.
T5 810-924 Sentence denotes The two drugs have similar glycosylation, both in the type and location of the oligosaccharide structures present.
T6 810-924 Sentence denotes The two drugs have similar glycosylation, both in the type and location of the oligosaccharide structures present.
TextSentencer_T7 925-1153 Sentence denotes Differences in glycosylation were mainly limited to the levels of sialic acid and mannose-6-phosphate present, with Fabrazyme having a higher percentage of fully sialylated oligosaccharides and a higher level of phosphorylation.
T6 925-1153 Sentence denotes Differences in glycosylation were mainly limited to the levels of sialic acid and mannose-6-phosphate present, with Fabrazyme having a higher percentage of fully sialylated oligosaccharides and a higher level of phosphorylation.
T7 925-1153 Sentence denotes Differences in glycosylation were mainly limited to the levels of sialic acid and mannose-6-phosphate present, with Fabrazyme having a higher percentage of fully sialylated oligosaccharides and a higher level of phosphorylation.
TextSentencer_T8 1154-1322 Sentence denotes The higher levels of phosphorylated oligomannose residues correlated with increased binding to mannose-6-phosphate receptors and uptake into Fabry fibroblasts in vitro.
T7 1154-1322 Sentence denotes The higher levels of phosphorylated oligomannose residues correlated with increased binding to mannose-6-phosphate receptors and uptake into Fabry fibroblasts in vitro.
T8 1154-1322 Sentence denotes The higher levels of phosphorylated oligomannose residues correlated with increased binding to mannose-6-phosphate receptors and uptake into Fabry fibroblasts in vitro.
TextSentencer_T9 1323-1409 Sentence denotes Biodistribution studies in a mouse model of Fabry disease showed similar organ uptake.
T8 1323-1409 Sentence denotes Biodistribution studies in a mouse model of Fabry disease showed similar organ uptake.
T9 1323-1409 Sentence denotes Biodistribution studies in a mouse model of Fabry disease showed similar organ uptake.
TextSentencer_T10 1410-1566 Sentence denotes Likewise, antigenicity studies using antisera from Fabry patients demonstrated that both drugs were indistinguishable in terms of antibody cross-reactivity.
T9 1410-1566 Sentence denotes Likewise, antigenicity studies using antisera from Fabry patients demonstrated that both drugs were indistinguishable in terms of antibody cross-reactivity.
T10 1410-1566 Sentence denotes Likewise, antigenicity studies using antisera from Fabry patients demonstrated that both drugs were indistinguishable in terms of antibody cross-reactivity.
TextSentencer_T11 1567-1774 Sentence denotes Based on these studies and present knowledge regarding the influence of glycosylation on protein biodistribution and cellular uptake, the two protein preparations appear to be functionally indistinguishable.
T10 1567-1774 Sentence denotes Based on these studies and present knowledge regarding the influence of glycosylation on protein biodistribution and cellular uptake, the two protein preparations appear to be functionally indistinguishable.
T11 1567-1774 Sentence denotes Based on these studies and present knowledge regarding the influence of glycosylation on protein biodistribution and cellular uptake, the two protein preparations appear to be functionally indistinguishable.
TextSentencer_T12 1775-1896 Sentence denotes Therefore, the data from these studies provide no rationale for the use of these proteins at different therapeutic doses.
T11 1775-1896 Sentence denotes Therefore, the data from these studies provide no rationale for the use of these proteins at different therapeutic doses.
T12 1775-1896 Sentence denotes Therefore, the data from these studies provide no rationale for the use of these proteins at different therapeutic doses.