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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-127 Sentence denotes MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.
T1 0-127 Sentence denotes MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.
TextSentencer_T2 128-317 Sentence denotes The novel mitogen/extracellular-signal-regulated kinase kinase 5/extracellular signal-regulated kinase-5 (MEK5/ERK5) pathway has been implicated in the regulation of cellular proliferation.
T2 128-317 Sentence denotes The novel mitogen/extracellular-signal-regulated kinase kinase 5/extracellular signal-regulated kinase-5 (MEK5/ERK5) pathway has been implicated in the regulation of cellular proliferation.
TextSentencer_T3 318-474 Sentence denotes MEK5 expression has been detected in prostate cancer cells, although the significance of the MEK5/ERK5 pathway in human prostate cancer has not been tested.
T3 318-474 Sentence denotes MEK5 expression has been detected in prostate cancer cells, although the significance of the MEK5/ERK5 pathway in human prostate cancer has not been tested.
TextSentencer_T4 475-658 Sentence denotes We examined MEK5 expression in 127 cases of prostate cancer and 20 cases of benign prostatic hypertrophy (BPH) by immunohistochemistry and compared the results to clinical parameters.
T4 475-658 Sentence denotes We examined MEK5 expression in 127 cases of prostate cancer and 20 cases of benign prostatic hypertrophy (BPH) by immunohistochemistry and compared the results to clinical parameters.
TextSentencer_T5 659-767 Sentence denotes We demonstrated that MEK5 expression is increased in prostate cancer as compared to benign prostatic tissue.
T5 659-767 Sentence denotes We demonstrated that MEK5 expression is increased in prostate cancer as compared to benign prostatic tissue.
TextSentencer_T6 768-885 Sentence denotes Strong MEK5 expression correlates with the presence of bony metastases and less favourable disease-specific survival.
T6 768-885 Sentence denotes Strong MEK5 expression correlates with the presence of bony metastases and less favourable disease-specific survival.
TextSentencer_T7 886-1018 Sentence denotes Furthermore, among the patients with high Gleason score of 8-10, MEK5 overexpression has an additional prognostic value in survival.
T7 886-1018 Sentence denotes Furthermore, among the patients with high Gleason score of 8-10, MEK5 overexpression has an additional prognostic value in survival.
TextSentencer_T8 1019-1180 Sentence denotes MEK5 transfection experiments confirm its ability to induce proliferation (P < 0.0001), motility (P = 0.0001) and invasion in prostate cancer cells (P = 0.0001).
T8 1019-1180 Sentence denotes MEK5 transfection experiments confirm its ability to induce proliferation (P < 0.0001), motility (P = 0.0001) and invasion in prostate cancer cells (P = 0.0001).
TextSentencer_T9 1181-1256 Sentence denotes MEK5 expression drastically increased MMP-9, but not MMP-2 mRNA expression.
T9 1181-1256 Sentence denotes MEK5 expression drastically increased MMP-9, but not MMP-2 mRNA expression.
TextSentencer_T10 1257-1497 Sentence denotes Luciferase report assays suggest that the -670/MMP-9 promoter is upregulated by MEK5 and electromobility shift assay further suggests the involvement of activator protein-I (AP-1), but not the NF-kappa B, binding site in the MMP-9 promoter.
T10 1257-1497 Sentence denotes Luciferase report assays suggest that the -670/MMP-9 promoter is upregulated by MEK5 and electromobility shift assay further suggests the involvement of activator protein-I (AP-1), but not the NF-kappa B, binding site in the MMP-9 promoter.
TextSentencer_T11 1498-1608 Sentence denotes Using an AP-1 luciferase construct, activation of MEK5 was confirmed to enhance AP-1 activities up to twofold.
T11 1498-1608 Sentence denotes Using an AP-1 luciferase construct, activation of MEK5 was confirmed to enhance AP-1 activities up to twofold.
TextSentencer_T12 1609-1721 Sentence denotes Taken together, our results establish MEK5 as a key signalling molecule associated with prostate carcinogenesis.
T12 1609-1721 Sentence denotes Taken together, our results establish MEK5 as a key signalling molecule associated with prostate carcinogenesis.
TextSentencer_T13 1722-1815 Sentence denotes As the MEK5/ERK5 interaction is highly specific, it represents a potential target of therapy.
T13 1722-1815 Sentence denotes As the MEK5/ERK5 interaction is highly specific, it represents a potential target of therapy.