| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-65 |
Sentence |
denotes |
The histone deacetylase 9 gene encodes multiple protein isoforms. |
| T2 |
66-204 |
Sentence |
denotes |
Histone deacetylases (HDACs) perform an important function in transcriptional regulation by modifying the core histones of the nucleosome. |
| T3 |
205-285 |
Sentence |
denotes |
We have now fully characterized a new member of the Class II HDAC family, HDAC9. |
| T4 |
286-463 |
Sentence |
denotes |
The enzyme contains a conserved deacetylase domain, represses reporter activity when recruited to a promoter, and utilizes histones H3 and H4 as substrates in vitro and in vivo. |
| T5 |
464-550 |
Sentence |
denotes |
HDAC9 is expressed in a tissue-specific pattern that partially overlaps that of HDAC4. |
| T6 |
551-668 |
Sentence |
denotes |
Within the human hematopoietic system, expression of HDAC9 is biased toward cells of monocytic and lymphoid lineages. |
| T7 |
669-781 |
Sentence |
denotes |
The HDAC9 gene encodes multiple protein isoforms, some of which display distinct cellular localization patterns. |
| T8 |
782-915 |
Sentence |
denotes |
For example, full-length HDAC9 is localized in the nucleus, but the isoform lacking the region encoded by exon 7 is in the cytoplasm. |
| T9 |
916-1132 |
Sentence |
denotes |
HDAC9 interacts and co-localizes in vivo with a number of transcriptional repressors and co-repressors, including TEL and N-CoR, whose functions have been implicated in the pathogenesis of hematological malignancies. |
| T10 |
1133-1266 |
Sentence |
denotes |
These results suggest that HDAC9 plays a role in hematopoiesis; its deregulated expression may be associated with some human cancers. |
