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PubMed:12556447 JSONTXT 39 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-96 Sentence denotes An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220.
T1 0-96 Sentence denotes An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220.
TextSentencer_T2 97-265 Sentence denotes The interaction of coactivators with the ligand-binding domain of nuclear receptors (NRs) is mediated by amphipathic alpha-helices containing the signature motif LXXLL.
T2 97-265 Sentence denotes The interaction of coactivators with the ligand-binding domain of nuclear receptors (NRs) is mediated by amphipathic alpha-helices containing the signature motif LXXLL.
TextSentencer_T3 266-363 Sentence denotes TRAP220 contains two LXXLL motifs (LXM1 and LXM2) that are required for its interaction with NRs.
T3 266-363 Sentence denotes TRAP220 contains two LXXLL motifs (LXM1 and LXM2) that are required for its interaction with NRs.
TextSentencer_T4 364-473 Sentence denotes Here we show that the nuclear receptor interaction domain (NID) of TRAP220 interacts weakly with Class I NRs.
T4 364-473 Sentence denotes Here we show that the nuclear receptor interaction domain (NID) of TRAP220 interacts weakly with Class I NRs.
TextSentencer_T5 474-544 Sentence denotes In contrast, SRC1 NID binds strongly to both Class I and Class II NRs.
T5 474-544 Sentence denotes In contrast, SRC1 NID binds strongly to both Class I and Class II NRs.
TextSentencer_T6 545-684 Sentence denotes Interaction assays using nine amino acid LXXLL core motifs derived from SRC1 and TRAP220 revealed no discriminatory NR binding preferences.
T6 545-684 Sentence denotes Interaction assays using nine amino acid LXXLL core motifs derived from SRC1 and TRAP220 revealed no discriminatory NR binding preferences.
TextSentencer_T7 685-889 Sentence denotes However, an extended LXM1 sequence containing amino acids -4 to +9, (where the first conserved leucine is +1) showed selective binding to thyroid hormone receptor and reduced binding to estrogen receptor.
T7 685-889 Sentence denotes However, an extended LXM1 sequence containing amino acids -4 to +9, (where the first conserved leucine is +1) showed selective binding to thyroid hormone receptor and reduced binding to estrogen receptor.
TextSentencer_T8 890-1063 Sentence denotes Replacement of either TRAP220 LXXLL motif with the corresponding 13 amino acids of SRC1 LXM2 strongly enhanced the interaction of the TRAP220 NID with the estrogen receptor.
T8 890-1063 Sentence denotes Replacement of either TRAP220 LXXLL motif with the corresponding 13 amino acids of SRC1 LXM2 strongly enhanced the interaction of the TRAP220 NID with the estrogen receptor.
TextSentencer_T9 1064-1225 Sentence denotes Mutational analysis revealed combinatorial effects of the LXM1 core and flanking sequences in the determination of the NR binding specificity of the TRAP220 NID.
T9 1064-1225 Sentence denotes Mutational analysis revealed combinatorial effects of the LXM1 core and flanking sequences in the determination of the NR binding specificity of the TRAP220 NID.
TextSentencer_T10 1226-1366 Sentence denotes In contrast, a mutation that increased the spacing between TRAP220 LXM1 and LXM2 had little effect on the binding properties of this domain.
T10 1226-1366 Sentence denotes In contrast, a mutation that increased the spacing between TRAP220 LXM1 and LXM2 had little effect on the binding properties of this domain.
TextSentencer_T11 1367-1502 Sentence denotes Thus, a 13-amino acid sequence comprising an extended LXXLL motif acts as the key determinant of the NR binding specificity of TRAP220.
T11 1367-1502 Sentence denotes Thus, a 13-amino acid sequence comprising an extended LXXLL motif acts as the key determinant of the NR binding specificity of TRAP220.
TextSentencer_T12 1503-1625 Sentence denotes Finally, we show that the NR binding specificity of full-length TRAP220 can be altered by swapping extended LXM sequences.
T12 1503-1625 Sentence denotes Finally, we show that the NR binding specificity of full-length TRAP220 can be altered by swapping extended LXM sequences.