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PubMed:12499401 JSONTXT 87 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-90 Sentence denotes Histidine 271 has a functional role in pig alpha-1,3galactosyltransferase enzyme activity.
T1 0-90 Sentence denotes Histidine 271 has a functional role in pig alpha-1,3galactosyltransferase enzyme activity.
TextSentencer_T2 91-258 Sentence denotes Alpha(1,3)Galactosyltransferase (GT) is a Golgi-localized enzyme that catalyzes the transfer of a terminal galactose to N-acetyllactosamine to create Galalpha(1,3)Gal.
T2 91-258 Sentence denotes Alpha(1,3)Galactosyltransferase (GT) is a Golgi-localized enzyme that catalyzes the transfer of a terminal galactose to N-acetyllactosamine to create Galalpha(1,3)Gal.
TextSentencer_T3 259-418 Sentence denotes This glycosyltransferase has been studied extensively because the Galalpha(1,3)Gal epitope is involved in hyperacute rejection of pig-to-human xenotransplants.
T3 259-418 Sentence denotes This glycosyltransferase has been studied extensively because the Galalpha(1,3)Gal epitope is involved in hyperacute rejection of pig-to-human xenotransplants.
TextSentencer_T4 419-625 Sentence denotes The original crystal structure of bovine GT defines the amino acids forming the catalytic pocket; however, those directly involved in the interaction with the donor nucleotide sugars were not characterized.
T4 419-625 Sentence denotes The original crystal structure of bovine GT defines the amino acids forming the catalytic pocket; however, those directly involved in the interaction with the donor nucleotide sugars were not characterized.
TextSentencer_T5 626-818 Sentence denotes Comparison of amino acid sequences of GT from several species with the human A and B transferases suggest that His271 of pig GT may be critical for recognition of the donor substrate, UDP-Gal.
T5 626-818 Sentence denotes Comparison of amino acid sequences of GT from several species with the human A and B transferases suggest that His271 of pig GT may be critical for recognition of the donor substrate, UDP-Gal.
TextSentencer_T6 819-1104 Sentence denotes Using pig GT as the representative member of the GT family, we show that replacement of His271 with Ala, Leu, or Gly caused complete loss of function, in contrast to replacement with Arg, another basic charged residue, which did not alter the ability of GT to produce Galalpha(1,3)Gal.
T6 819-1104 Sentence denotes Using pig GT as the representative member of the GT family, we show that replacement of His271 with Ala, Leu, or Gly caused complete loss of function, in contrast to replacement with Arg, another basic charged residue, which did not alter the ability of GT to produce Galalpha(1,3)Gal.
TextSentencer_T7 1105-1256 Sentence denotes Molecular modeling showed that His271 may interact directly with the Gal moiety of UDP-Gal, an interaction possibly retained by replacing His with Arg.
T7 1105-1256 Sentence denotes Molecular modeling showed that His271 may interact directly with the Gal moiety of UDP-Gal, an interaction possibly retained by replacing His with Arg.
TextSentencer_T8 1257-1387 Sentence denotes However, replacing His271 with amino acids found in alpha(1,3)GalNAc transferases did not change the donor nucleotide specificity.
T8 1257-1387 Sentence denotes However, replacing His271 with amino acids found in alpha(1,3)GalNAc transferases did not change the donor nucleotide specificity.
TextSentencer_T9 1388-1445 Sentence denotes Thus His271 is critical for enzymatic function of pig GT.
T9 1388-1445 Sentence denotes Thus His271 is critical for enzymatic function of pig GT.