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PubMed:12438264 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-154 Sentence denotes Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.
T1 0-154 Sentence denotes Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.
TextSentencer_T2 155-290 Sentence denotes Signal transducers and activators of transcription (STATs) were identified originally as key components of cytokine signaling pathways.
T2 155-290 Sentence denotes Signal transducers and activators of transcription (STATs) were identified originally as key components of cytokine signaling pathways.
TextSentencer_T3 291-429 Sentence denotes More recently, constitutive activation of STAT proteins has been detected in a wide variety of human tumor specimens and tumor cell lines.
T3 291-429 Sentence denotes More recently, constitutive activation of STAT proteins has been detected in a wide variety of human tumor specimens and tumor cell lines.
TextSentencer_T4 430-561 Sentence denotes Here, we examined the activation of one STAT family member, Stat3, in human prostate cancer cell lines and primary prostate tumors.
T4 430-561 Sentence denotes Here, we examined the activation of one STAT family member, Stat3, in human prostate cancer cell lines and primary prostate tumors.
TextSentencer_T5 562-777 Sentence denotes An analysis of 45 adenocarcinomas obtained at radical prostatectomy revealed elevated levels of constitutive Stat3 activation in 37 (82%) of 45 of the tumors compared with matched adjacent nontumor prostate tissues.
T5 562-777 Sentence denotes An analysis of 45 adenocarcinomas obtained at radical prostatectomy revealed elevated levels of constitutive Stat3 activation in 37 (82%) of 45 of the tumors compared with matched adjacent nontumor prostate tissues.
TextSentencer_T6 778-966 Sentence denotes A highly specific immunohistochemical assay for detection of phospho-Stat3 revealed that elevated Stat3 activity was localized primarily in the tumor cells of prostate carcinoma specimens.
T6 778-966 Sentence denotes A highly specific immunohistochemical assay for detection of phospho-Stat3 revealed that elevated Stat3 activity was localized primarily in the tumor cells of prostate carcinoma specimens.
TextSentencer_T7 967-1125 Sentence denotes Furthermore, higher levels of Stat3 activation in patient specimens were correlated significantly with more malignant tumors exhibiting higher Gleason scores.
T7 967-1125 Sentence denotes Furthermore, higher levels of Stat3 activation in patient specimens were correlated significantly with more malignant tumors exhibiting higher Gleason scores.
TextSentencer_T8 1126-1265 Sentence denotes In addition, all of the three human prostate cancer cell lines examined (DU145, PC3, and LNCaP) displayed constitutive activation of Stat3.
T8 1126-1265 Sentence denotes In addition, all of the three human prostate cancer cell lines examined (DU145, PC3, and LNCaP) displayed constitutive activation of Stat3.
TextSentencer_T9 1266-1459 Sentence denotes Substantially lower levels of Stat3 activation were detected in LNCaP cells; however, stimulation with interleukin 6 induced a significant increase in Stat3 DNA-binding activity in these cells.
T9 1266-1459 Sentence denotes Substantially lower levels of Stat3 activation were detected in LNCaP cells; however, stimulation with interleukin 6 induced a significant increase in Stat3 DNA-binding activity in these cells.
TextSentencer_T10 1460-1618 Sentence denotes Moreover, the direct inhibition of constitutive Stat3 signaling in DU145 cells using antisense Stat3 oligonucleotides induced growth inhibition and apoptosis.
T10 1460-1618 Sentence denotes Moreover, the direct inhibition of constitutive Stat3 signaling in DU145 cells using antisense Stat3 oligonucleotides induced growth inhibition and apoptosis.
TextSentencer_T11 1619-1805 Sentence denotes Our findings demonstrate that constitutive activation of Stat3 occurs frequently in primary prostate adenocarcinomas and is critical for the growth and survival of prostate cancer cells.
T11 1619-1805 Sentence denotes Our findings demonstrate that constitutive activation of Stat3 occurs frequently in primary prostate adenocarcinomas and is critical for the growth and survival of prostate cancer cells.
TextSentencer_T12 1806-1933 Sentence denotes These studies further suggest that Stat3 signaling represents a potentially novel molecular target for prostate cancer therapy.
T12 1806-1933 Sentence denotes These studies further suggest that Stat3 signaling represents a potentially novel molecular target for prostate cancer therapy.