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Id Subject Object Predicate Lexical cue
T1 0-138 Sentence denotes Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha).
T2 139-278 Sentence denotes The nuclear co-activator PGC-1alpha is a pivotal regulator of numerous pathways controlling both metabolism and overall energy homeostasis.
T3 279-428 Sentence denotes Inappropriate increases in PGC-1alpha activity have been linked to a number of pathological conditions including heart failure and diabetes mellitus.
T4 429-534 Sentence denotes Previous studies (Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O'Malley, B., and Spiegelman, B.
T5 535-663 Sentence denotes M. (1999) Science 286, 1368-1371) have demonstrated an inhibitory domain within PGC-1alpha that limits transcriptional activity.
T6 664-851 Sentence denotes Using this inhibitory domain in a yeast two-hybrid screen, we demonstrate that PGC-1alpha directly associates with the orphan nuclear receptor estrogen-related receptor-alpha (ERR-alpha).
T7 852-939 Sentence denotes The binding of ERR-alpha to PGC-1alpha requires the C-terminal AF2 domain of ERR-alpha.
T8 940-1129 Sentence denotes PGC-1alpha and ERR-alpha have a similar pattern of expression in human tissues, with both being present predominantly in organs with high metabolic needs such as skeletal muscle and kidney.
T9 1130-1260 Sentence denotes Similarly, we show that in mice physiological stimuli such as fasting coordinately induces PGC-1alpha and ERR-alpha transcription.
T10 1261-1476 Sentence denotes We also demonstrate that under normal conditions PGC-1alpha is located within discrete nuclear speckles, whereas the expression of ERR-alpha results in PGC-1alpha redistributing uniformly throughout the nucleoplasm.
T11 1477-1605 Sentence denotes Finally, we show that the expression of ERR-alpha can dramatically and specifically repress PGC-1alpha transcriptional activity.
T12 1606-1761 Sentence denotes These results suggest a novel mechanism of transcriptional control wherein ERR-alpha can function as a specific molecular repressor of PGC-1alpha activity.
T13 1762-1949 Sentence denotes In addition, our results suggest that other co-activators might also have specific repressors, thereby identifying another layer of combinatorial complexity in transcriptional regulation.