| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-92 |
Sentence |
denotes |
Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family. |
| T2 |
93-224 |
Sentence |
denotes |
Hair fiber differentiation and maturation involves the close interaction between hair keratins and their associated proteins, KAPs. |
| T3 |
225-401 |
Sentence |
denotes |
Recently, a cluster of seven human KAP multigen families has been identified on chromosome 17q12-21 among which were four hKAP1 genes (hKAP1.1B, hKAP1.3, hKAP1.4, and hKAP1.5). |
| T4 |
402-568 |
Sentence |
denotes |
In addition, there were previous as well as recent reports on four additional hKAP1 genes (hKAP1.1A, hKAP1.2, hKAP1.6, and hKAP1.7) with unknown chromosomal location. |
| T5 |
569-774 |
Sentence |
denotes |
In this study, we have analyzed these eight hKAP1 genes in unrelated Japanese and Caucasian individuals and discovered that hKAP1.1A, hKAP1.6, and hKAP1.7 represent size polymorphisms of the hKAP1.1B gene. |
| T6 |
775-926 |
Sentence |
denotes |
In addition, we show that hKAP1.2 as well as three hitherto unknown genes (hKAP1.8A, hKAP1.8B, and hKAP1.9) are size polymorphisms of the hKAP1.3 gene. |
| T7 |
927-1008 |
Sentence |
denotes |
In contrast, no polymorphic alleles were found for the hKAP1.4 and hKAP1.5 genes. |
| T8 |
1009-1198 |
Sentence |
denotes |
We provide evidence that the polymorphic hKAP1.1B and hKAP1.3 alleles arose mainly by intragenic deletion and/or duplication events of distinct pentapeptide repeats typical for hKAP1 genes. |
| T9 |
1199-1400 |
Sentence |
denotes |
We also demonstrate the occurrence of both frequent and rare population-specific hKAP1.1B and hKAP1.3 alleles, which were obviously generated after the divergence of the Caucasian and Japanese lineage. |
| T10 |
1401-1572 |
Sentence |
denotes |
In addition, by means of a pan-hKAP1 antibody, we confirm the previous hKAP1 family mRNA localization data in the middle to upper cortex of the human anagen hair follicle. |
