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PubMed:12127369 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-83 Sentence denotes C/T polymorphism of the intercellular adhesion molecule-1 gene (exon 6, codon 469).
T1 0-83 Sentence denotes C/T polymorphism of the intercellular adhesion molecule-1 gene (exon 6, codon 469).
TextSentencer_T2 84-151 Sentence denotes A risk factor for coronary heart disease and myocardial infarction.
T2 84-151 Sentence denotes A risk factor for coronary heart disease and myocardial infarction.
TextSentencer_T3 152-163 Sentence denotes BACKGROUND:
T3 152-163 Sentence denotes BACKGROUND:
TextSentencer_T4 164-360 Sentence denotes The intercellular adhesion molecule-1 (ICAM-1) mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of coronary atherosclerosis.
T4 164-360 Sentence denotes The intercellular adhesion molecule-1 (ICAM-1) mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of coronary atherosclerosis.
TextSentencer_T5 361-504 Sentence denotes ICAM-1 single-base C/T polymorphism, which determines an amino acid substitution in the ICAM-1 protein in exon 6 codon 469, has been described.
T5 361-504 Sentence denotes ICAM-1 single-base C/T polymorphism, which determines an amino acid substitution in the ICAM-1 protein in exon 6 codon 469, has been described.
TextSentencer_T6 505-657 Sentence denotes Our purpose was to determine whether this C/T polymorphism influences the risk of coronary heart disease (CHD) and myocardial infarction (MI) in humans.
T6 505-657 Sentence denotes Our purpose was to determine whether this C/T polymorphism influences the risk of coronary heart disease (CHD) and myocardial infarction (MI) in humans.
TextSentencer_T7 658-678 Sentence denotes METHODS AND RESULTS:
T7 658-678 Sentence denotes METHODS AND RESULTS:
TextSentencer_T8 679-805 Sentence denotes We enrolled 349 patients with angiographically documented CHD, including a sub-group of 179 patients with acute or chronic MI.
T8 679-805 Sentence denotes We enrolled 349 patients with angiographically documented CHD, including a sub-group of 179 patients with acute or chronic MI.
TextSentencer_T9 806-922 Sentence denotes The control group consisted of 213 patients with normal left ventricular function and no documented evidence of CHD.
T9 806-922 Sentence denotes The control group consisted of 213 patients with normal left ventricular function and no documented evidence of CHD.
TextSentencer_T10 923-1076 Sentence denotes All patients and controls were Germans genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques for the ICAM-1 polymorphism.
T10 923-1076 Sentence denotes All patients and controls were Germans genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques for the ICAM-1 polymorphism.
TextSentencer_T11 1077-1241 Sentence denotes In the patients with CHD and MI the frequencies of the T genotype (TT+TC) were significantly higher than the CC genotype compared to the control subjects (P<0.001).
T11 1077-1241 Sentence denotes In the patients with CHD and MI the frequencies of the T genotype (TT+TC) were significantly higher than the CC genotype compared to the control subjects (P<0.001).
TextSentencer_T12 1242-1496 Sentence denotes With the additional use of multivariable logistic regression analysis for CHD (TT+TC versus CC; P=0.011, odds ratio 2.21, 95% CI 1.20-4.07), we found a significant association between CHD and MI and the TT and TC genotype of the ICAM-1 gene polymorphism.
T12 1242-1496 Sentence denotes With the additional use of multivariable logistic regression analysis for CHD (TT+TC versus CC; P=0.011, odds ratio 2.21, 95% CI 1.20-4.07), we found a significant association between CHD and MI and the TT and TC genotype of the ICAM-1 gene polymorphism.
TextSentencer_T13 1497-1509 Sentence denotes CONCLUSIONS:
T13 1497-1509 Sentence denotes CONCLUSIONS:
TextSentencer_T14 1510-1690 Sentence denotes These results suggest that the TT and TC genotype of the ICAM-1 gene polymorphism in codon 469 is a genetic factor that may determine an individual's susceptibility for CHD and MI.
T14 1510-1690 Sentence denotes These results suggest that the TT and TC genotype of the ICAM-1 gene polymorphism in codon 469 is a genetic factor that may determine an individual's susceptibility for CHD and MI.