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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-92 Sentence denotes Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised children.
T1 0-92 Sentence denotes Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised children.
TextSentencer_T2 93-104 Sentence denotes BACKGROUND:
T2 93-104 Sentence denotes BACKGROUND:
TextSentencer_T3 105-195 Sentence denotes Adenovirus is an important cause of morbidity and mortality in the immunocompromised host.
T3 105-195 Sentence denotes Adenovirus is an important cause of morbidity and mortality in the immunocompromised host.
TextSentencer_T4 196-401 Sentence denotes The incidence of severe adenovirus disease in pediatrics is increasing in association with growing numbers of immunocompromised children, where case fatality rates as high as 50% to 80% have been reported.
T4 196-401 Sentence denotes The incidence of severe adenovirus disease in pediatrics is increasing in association with growing numbers of immunocompromised children, where case fatality rates as high as 50% to 80% have been reported.
TextSentencer_T5 402-618 Sentence denotes There are no approved antiviral agents with proven efficacy for the treatment of severe adenovirus disease, nor are there any prospective randomized, controlled trials of potentially useful anti-adenovirus therapies.
T5 402-618 Sentence denotes There are no approved antiviral agents with proven efficacy for the treatment of severe adenovirus disease, nor are there any prospective randomized, controlled trials of potentially useful anti-adenovirus therapies.
TextSentencer_T6 619-741 Sentence denotes Apparent clinical success in the treatment of severe adenovirus disease is limited to a few case reports and small series.
T6 619-741 Sentence denotes Apparent clinical success in the treatment of severe adenovirus disease is limited to a few case reports and small series.
TextSentencer_T7 742-806 Sentence denotes Experience is greatest with intravenous ribavirin and cidofovir.
T7 742-806 Sentence denotes Experience is greatest with intravenous ribavirin and cidofovir.
TextSentencer_T8 807-961 Sentence denotes Ribavirin, a guanosine analogue, has broad antiviral activity against both RNA and DNA viruses, including documented activity against adenovirus in vitro.
T8 807-961 Sentence denotes Ribavirin, a guanosine analogue, has broad antiviral activity against both RNA and DNA viruses, including documented activity against adenovirus in vitro.
TextSentencer_T9 962-1123 Sentence denotes Ribavirin is licensed in aerosol form for the treatment of respiratory syncytial virus infection, and orally in combination with interferon to treat hepatitis C.
T9 962-1123 Sentence denotes Ribavirin is licensed in aerosol form for the treatment of respiratory syncytial virus infection, and orally in combination with interferon to treat hepatitis C.
TextSentencer_T10 1124-1218 Sentence denotes Intravenous ribavirin is the treatment of choice for infection with hemorrhagic fever viruses.
T10 1124-1218 Sentence denotes Intravenous ribavirin is the treatment of choice for infection with hemorrhagic fever viruses.
TextSentencer_T11 1219-1301 Sentence denotes The most common adverse effect of intravenous ribavirin is reversible mild anemia.
T11 1219-1301 Sentence denotes The most common adverse effect of intravenous ribavirin is reversible mild anemia.
TextSentencer_T12 1302-1439 Sentence denotes The use of cidofovir in severe adenovirus infection has been limited by adverse effects, the most significant of which is nephrotoxicity.
T12 1302-1439 Sentence denotes The use of cidofovir in severe adenovirus infection has been limited by adverse effects, the most significant of which is nephrotoxicity.
TextSentencer_T13 1440-1450 Sentence denotes OBJECTIVE:
T13 1440-1450 Sentence denotes OBJECTIVE:
TextSentencer_T14 1451-1609 Sentence denotes We report our experience with intravenous ribavirin therapy for severe adenovirus disease in a series of immunocompromised children and review the literature.
T14 1451-1609 Sentence denotes We report our experience with intravenous ribavirin therapy for severe adenovirus disease in a series of immunocompromised children and review the literature.
TextSentencer_T15 1610-1625 Sentence denotes DESIGN/METHODS:
T15 1610-1625 Sentence denotes DESIGN/METHODS:
TextSentencer_T16 1626-1764 Sentence denotes We retrospectively reviewed the medical records of 5 children treated with intravenous ribavirin for documented severe adenovirus disease.
T16 1626-1764 Sentence denotes We retrospectively reviewed the medical records of 5 children treated with intravenous ribavirin for documented severe adenovirus disease.
TextSentencer_T17 1765-1876 Sentence denotes Two patients developed adenovirus hemorrhagic cystitis after cardiac and bone marrow transplants, respectively.
T17 1765-1876 Sentence denotes Two patients developed adenovirus hemorrhagic cystitis after cardiac and bone marrow transplants, respectively.
TextSentencer_T18 1877-1985 Sentence denotes The bone marrow transplant patient also received intravenous cidofovir for progressive disseminated disease.
T18 1877-1985 Sentence denotes The bone marrow transplant patient also received intravenous cidofovir for progressive disseminated disease.
TextSentencer_T19 1986-2100 Sentence denotes An additional 3 children developed adenovirus pneumonia; 2 were neonates, 1 of whom had partial DiGeorge syndrome.
T19 1986-2100 Sentence denotes An additional 3 children developed adenovirus pneumonia; 2 were neonates, 1 of whom had partial DiGeorge syndrome.
TextSentencer_T20 2101-2166 Sentence denotes The remaining infant had recently undergone a cardiac transplant.
T20 2101-2166 Sentence denotes The remaining infant had recently undergone a cardiac transplant.
TextSentencer_T21 2167-2238 Sentence denotes Intravenous ribavirin was administered on a compassionate-use protocol.
T21 2167-2238 Sentence denotes Intravenous ribavirin was administered on a compassionate-use protocol.
TextSentencer_T22 2239-2247 Sentence denotes RESULTS:
T22 2239-2247 Sentence denotes RESULTS:
TextSentencer_T23 2248-2465 Sentence denotes Complete clinical recovery followed later by viral clearance was observed in 2 children: the cardiac transplant recipient with adenovirus hemorrhagic cystitis and the immunocompetent neonate with adenovirus pneumonia.
T23 2248-2465 Sentence denotes Complete clinical recovery followed later by viral clearance was observed in 2 children: the cardiac transplant recipient with adenovirus hemorrhagic cystitis and the immunocompetent neonate with adenovirus pneumonia.
TextSentencer_T24 2466-2518 Sentence denotes The remaining 3 children died of adenovirus disease.
T24 2466-2518 Sentence denotes The remaining 3 children died of adenovirus disease.
TextSentencer_T25 2519-2568 Sentence denotes Intravenous ribavirin therapy was well tolerated.
T25 2519-2568 Sentence denotes Intravenous ribavirin therapy was well tolerated.
TextSentencer_T26 2569-2659 Sentence denotes Use of cidofovir in 1 child was associated with progressive renal failure and neutropenia.
T26 2569-2659 Sentence denotes Use of cidofovir in 1 child was associated with progressive renal failure and neutropenia.
TextSentencer_T27 2660-2671 Sentence denotes DISCUSSION:
T27 2660-2671 Sentence denotes DISCUSSION:
TextSentencer_T28 2672-2910 Sentence denotes Our series of patients is representative of the spectrum of immunocompromised children at greatest risk for severe adenovirus disease, namely solid-organ and bone marrow transplant recipients, neonates, and children with immunodeficiency.
T28 2672-2910 Sentence denotes Our series of patients is representative of the spectrum of immunocompromised children at greatest risk for severe adenovirus disease, namely solid-organ and bone marrow transplant recipients, neonates, and children with immunodeficiency.
TextSentencer_T29 2911-3127 Sentence denotes Although intravenous ribavirin was not effective for all children with severe adenovirus disease in this series or in the literature, therapy is unlikely to be of benefit if begun late in the course of the infection.
T29 2911-3127 Sentence denotes Although intravenous ribavirin was not effective for all children with severe adenovirus disease in this series or in the literature, therapy is unlikely to be of benefit if begun late in the course of the infection.
TextSentencer_T30 3128-3328 Sentence denotes Early identification, eg by polymerase chain reaction of those patients at risk of disseminated adenovirus disease may permit earlier antiviral treatment and better evaluation of therapeutic response.
T30 3128-3328 Sentence denotes Early identification, eg by polymerase chain reaction of those patients at risk of disseminated adenovirus disease may permit earlier antiviral treatment and better evaluation of therapeutic response.
TextSentencer_T31 3329-3341 Sentence denotes CONCLUSIONS:
T31 3329-3341 Sentence denotes CONCLUSIONS:
TextSentencer_T32 3342-3436 Sentence denotes Two of 5 children with severe adenovirus disease treated with intravenous ribavirin recovered.
T32 3342-3436 Sentence denotes Two of 5 children with severe adenovirus disease treated with intravenous ribavirin recovered.
TextSentencer_T33 3437-3603 Sentence denotes The availability of newer rapid diagnostic techniques, such as polymerase chain reaction, may make earlier, more effective treatment of adenovirus infection possible.
T33 3437-3603 Sentence denotes The availability of newer rapid diagnostic techniques, such as polymerase chain reaction, may make earlier, more effective treatment of adenovirus infection possible.
TextSentencer_T34 3604-3907 Sentence denotes Given the seriousness and increasing prevalence of adenovirus disease in certain hosts, especially children, a large, multicenter clinical trial of potentially useful anti-adenoviral therapies, such as intravenous ribavirin, is clearly required to demonstrate the most effective and least toxic therapy.
T34 3604-3907 Sentence denotes Given the seriousness and increasing prevalence of adenovirus disease in certain hosts, especially children, a large, multicenter clinical trial of potentially useful anti-adenoviral therapies, such as intravenous ribavirin, is clearly required to demonstrate the most effective and least toxic therapy.