| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-77 |
Sentence |
denotes |
Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. |
| T2 |
78-134 |
Sentence |
denotes |
A novel member of the HNK-1 family of sulfotransferases. |
| T3 |
135-366 |
Sentence |
denotes |
We have identified and characterized an N-acetylgalactosamine-4-O-sulfotransferase designated chondroitin-4-sulfotransferase-3 (C4ST-3) (GenBank accession number AY120869) based on its homology to HNK-1 sulfotransferase (HNK-1 ST). |
| T4 |
367-596 |
Sentence |
denotes |
The cDNA predicts an open reading frame encoding a type II membrane protein of 341 amino acids with a 12-amino acid cytoplasmic domain and a 311-amino acid luminal domain containing a single potential N-linked glycosylation site. |
| T5 |
597-983 |
Sentence |
denotes |
C4ST-3 has the greatest amino acid sequence identity when aligned with chondroitin-4-O-sulfotransferase 1 (C4ST-1) (45%) but also shows significant amino acid identity with chondroitin-4-O-sulfotransferase 2 (C4ST-2) (27%), dermatan-4-O-sulfotransferase 1 (29%), HNK-1 ST (26%), N-acetylgalactosamine-4-O-sulfotransferase 1 (26%), and N-acetylgalactosamine-4-O-sulfotransferase 2 (23%). |
| T6 |
984-1129 |
Sentence |
denotes |
C4ST-3 transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. |
| T7 |
1130-1224 |
Sentence |
denotes |
The open reading frame of C4ST-3 is encoded by three exons located on human chromosome 3q21.3. |
| T8 |
1225-1289 |
Sentence |
denotes |
Northern blot analysis reveals a single 2.1-kilobase transcript. |
| T9 |
1290-1399 |
Sentence |
denotes |
C4ST-3 message is expressed in adult liver and at lower levels in adult kidney, lymph nodes, and fetal liver. |
| T10 |
1400-1565 |
Sentence |
denotes |
Although C4ST-3 and C4ST-1 have similar specificities, the highly restricted pattern of expression seen for C4ST-3 suggests that it has a different role than C4ST-1. |
