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PubMed:12058028 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.
T2 96-275 Sentence denotes Stress signals activate the SAPK/JNK and p38 MAPK classes of protein kinases, which mediate cellular responses, including steps in apoptosis and the maturation of some cell types.
T3 276-448 Sentence denotes We now show that stress signals initiated by transforming growth factor-beta 1 (TGF-beta 1) induce G(1) arrest through protein stabilization of the CDK inhibitor p21(Cip1).
T4 449-669 Sentence denotes TGF-beta 1 was previously shown to increase p21 protein levels, which in turn mediated G(1) arrest through inactivation of the CDK2-cyclin E complex in HD3 cells (Yan, Z., Kim, G.-Y., Deng, X., and Friedman, E. (2002) J.
T5 670-675 Sentence denotes Biol.
T6 676-681 Sentence denotes Chem.
T7 682-698 Sentence denotes 277, 9870-9879).
T8 699-817 Sentence denotes We now demonstrate that the increase in p21 abundance is caused by a post-transcriptional, SMAD-independent mechanism.
T9 818-901 Sentence denotes TGF-beta1 activated p38 alpha and JNK1, which initiated the phosphorylation of p21.
T10 902-965 Sentence denotes TGF-beta1 treatment increased the half-life of p21 by 3-4-fold.
T11 966-1265 Sentence denotes The increase in p21 stability was detected following activation of p38 alpha and JNK1, and treatment of cells with the p38 inhibitor SB203580 prevented this increase in p21 stability. p38 alpha and JNK1 phosphorylated p21 in vivo, and both p38 alpha and JNK1 phosphorylated p21 at Ser(130) in vitro.
T12 1266-1462 Sentence denotes Peptide mapping demonstrated that both TGF-beta 1 and p38 alpha induced phosphorylation of p21 at Ser(130) in vivo, and mutation of Ser(130) to alanine rendered p21 less stable than wild-type p21.
T13 1463-1545 Sentence denotes TGF-beta 1 increased the stability of wild-type p21, but not the p21-S130A mutant.
T14 1546-1661 Sentence denotes These findings demonstrate that SAPKs can mediate cell cycle arrest through post-translational modification of p21.