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PubMed:11967535 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-80 Sentence denotes Cardiac troponin T is essential in sarcomere assembly and cardiac contractility.
T1 0-80 Sentence denotes Cardiac troponin T is essential in sarcomere assembly and cardiac contractility.
TextSentencer_T2 81-307 Sentence denotes Mutations of the gene (TNNT2) encoding the thin-filament contractile protein cardiac troponin T are responsible for 15% of all cases of familial hypertrophic cardiomyopathy, the leading cause of sudden death in young athletes.
T2 81-307 Sentence denotes Mutations of the gene (TNNT2) encoding the thin-filament contractile protein cardiac troponin T are responsible for 15% of all cases of familial hypertrophic cardiomyopathy, the leading cause of sudden death in young athletes.
TextSentencer_T3 308-414 Sentence denotes Mutant proteins are thought to act through a dominant-negative mode that impairs function of heart muscle.
T3 308-414 Sentence denotes Mutant proteins are thought to act through a dominant-negative mode that impairs function of heart muscle.
TextSentencer_T4 415-505 Sentence denotes TNNT2 mutations can also lead to dilated cardiomyopathy, a leading cause of heart failure.
T4 415-505 Sentence denotes TNNT2 mutations can also lead to dilated cardiomyopathy, a leading cause of heart failure.
TextSentencer_T5 506-623 Sentence denotes Despite the importance of cardiac troponin T in human disease, its loss-of-function phenotype has not been described.
T5 506-623 Sentence denotes Despite the importance of cardiac troponin T in human disease, its loss-of-function phenotype has not been described.
TextSentencer_T6 624-702 Sentence denotes We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.
T6 624-702 Sentence denotes We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.
TextSentencer_T7 703-853 Sentence denotes We characterize two mutated alleles of sih that severely reduce tnnt2 expression: one affects mRNA splicing, and the other affects gene transcription.
T7 703-853 Sentence denotes We characterize two mutated alleles of sih that severely reduce tnnt2 expression: one affects mRNA splicing, and the other affects gene transcription.
TextSentencer_T8 854-1002 Sentence denotes Tnnt2, together with alpha-tropomyosin (Tpma) and cardiac troponins C and I (Tnni3), forms a calcium-sensitive regulatory complex within sarcomeres.
T8 854-1002 Sentence denotes Tnnt2, together with alpha-tropomyosin (Tpma) and cardiac troponins C and I (Tnni3), forms a calcium-sensitive regulatory complex within sarcomeres.
TextSentencer_T9 1003-1177 Sentence denotes Unexpectedly, in addition to loss of Tnnt2 expression in sih mutant hearts, we observed a significant reduction in Tpma and Tnni3, and consequently, severe sarcomere defects.
T9 1003-1177 Sentence denotes Unexpectedly, in addition to loss of Tnnt2 expression in sih mutant hearts, we observed a significant reduction in Tpma and Tnni3, and consequently, severe sarcomere defects.
TextSentencer_T10 1178-1466 Sentence denotes This interdependence of thin-filament protein expression led us to postulate that some mutations in tnnt2 may trigger misregulation of thin-filament protein expression, resulting in sarcomere loss and myocyte disarray, the life-threatening hallmarks of TNNT2 mutations in mice and humans.
T10 1178-1466 Sentence denotes This interdependence of thin-filament protein expression led us to postulate that some mutations in tnnt2 may trigger misregulation of thin-filament protein expression, resulting in sarcomere loss and myocyte disarray, the life-threatening hallmarks of TNNT2 mutations in mice and humans.