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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-143 Sentence denotes Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions.
T1 0-143 Sentence denotes Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions.
TextSentencer_T2 144-203 Sentence denotes Angiogenic factors are involved in tumor growth and spread.
T2 144-203 Sentence denotes Angiogenic factors are involved in tumor growth and spread.
TextSentencer_T3 204-391 Sentence denotes The aim of this study was to evaluate the expression of angiogenesis-related genes in malignant serous effusions of patients with advanced-stage (FIGO stage III and IV) ovarian carcinoma.
T3 204-391 Sentence denotes The aim of this study was to evaluate the expression of angiogenesis-related genes in malignant serous effusions of patients with advanced-stage (FIGO stage III and IV) ovarian carcinoma.
TextSentencer_T4 392-553 Sentence denotes In addition, to compare the results for carcinoma cells in effusions with corresponding primary tumors and metastatic lesions, and analyze their prognostic role.
T4 392-553 Sentence denotes In addition, to compare the results for carcinoma cells in effusions with corresponding primary tumors and metastatic lesions, and analyze their prognostic role.
TextSentencer_T5 554-850 Sentence denotes Sections from 66 effusions and 90 primary and metastatic lesions from 62 ovarian and primary peritoneal carcinoma patients, were evaluated for expression of basic fibroblast factor (bFGF), interleukin-8 (IL-8), and vascular endothelial growth factor (VEGF) using mRNA in situ hybridization (ISH).
T5 554-850 Sentence denotes Sections from 66 effusions and 90 primary and metastatic lesions from 62 ovarian and primary peritoneal carcinoma patients, were evaluated for expression of basic fibroblast factor (bFGF), interleukin-8 (IL-8), and vascular endothelial growth factor (VEGF) using mRNA in situ hybridization (ISH).
TextSentencer_T6 851-942 Sentence denotes Protein expression was evaluated in a subset of specimens using immunohistochemistry (IHC).
T6 851-942 Sentence denotes Protein expression was evaluated in a subset of specimens using immunohistochemistry (IHC).
TextSentencer_T7 943-996 Sentence denotes ISH results were correlated with clinical parameters.
T7 943-996 Sentence denotes ISH results were correlated with clinical parameters.
TextSentencer_T8 997-1238 Sentence denotes In both effusions and solid tumors, bFGF mRNA was the most commonly expressed factor (93% of effusions and 95% of solid tumors) followed by IL-8, while VEGF was expressed in a minority of the specimens (P < 0.001 for bFGF vs. IL-8 and VEGF).
T8 997-1238 Sentence denotes In both effusions and solid tumors, bFGF mRNA was the most commonly expressed factor (93% of effusions and 95% of solid tumors) followed by IL-8, while VEGF was expressed in a minority of the specimens (P < 0.001 for bFGF vs. IL-8 and VEGF).
TextSentencer_T9 1239-1358 Sentence denotes In solid tumors, angiogenic mRNA expression was seen in both tumor and stromal cells in the majority of positive cases.
T9 1239-1358 Sentence denotes In solid tumors, angiogenic mRNA expression was seen in both tumor and stromal cells in the majority of positive cases.
TextSentencer_T10 1359-1419 Sentence denotes ISH results did not differ in primary and metastatic tumors.
T10 1359-1419 Sentence denotes ISH results did not differ in primary and metastatic tumors.
TextSentencer_T11 1420-1578 Sentence denotes However, carcinoma cells in effusions showed down-regulated expression of VEGF, when compared with both primary tumors (P = 0.029) and metastases (P = 0.015).
T11 1420-1578 Sentence denotes However, carcinoma cells in effusions showed down-regulated expression of VEGF, when compared with both primary tumors (P = 0.029) and metastases (P = 0.015).
TextSentencer_T12 1579-1673 Sentence denotes IL-8 showed a similar down-regulation in effusions, when compared with metastases (P = 0.005).
T12 1579-1673 Sentence denotes IL-8 showed a similar down-regulation in effusions, when compared with metastases (P = 0.005).
TextSentencer_T13 1674-1741 Sentence denotes IHC showed excellent agreement with mRNA findings on protein level.
T13 1674-1741 Sentence denotes IHC showed excellent agreement with mRNA findings on protein level.
TextSentencer_T14 1742-1874 Sentence denotes In the study of clinico-pathologic parameters, IL-8 mRNA expression in effusions was associated with higher tumor grade (P = 0.044).
T14 1742-1874 Sentence denotes In the study of clinico-pathologic parameters, IL-8 mRNA expression in effusions was associated with higher tumor grade (P = 0.044).
TextSentencer_T15 1875-2058 Sentence denotes Angiogenic gene expression in effusions showed no correlation with patient age, previous treatment, residual tumor size, FIGO stage or disease outcome in survival analysis (P > 0.05).
T15 1875-2058 Sentence denotes Angiogenic gene expression in effusions showed no correlation with patient age, previous treatment, residual tumor size, FIGO stage or disease outcome in survival analysis (P > 0.05).
TextSentencer_T16 2059-2127 Sentence denotes Peritoneal and pleural effusions showed similar expression patterns.
T16 2059-2127 Sentence denotes Peritoneal and pleural effusions showed similar expression patterns.
TextSentencer_T17 2128-2228 Sentence denotes In conclusion, bFGF is the major angiogenic factor expressed in ovarian carcinoma at the mRNA level.
T17 2128-2228 Sentence denotes In conclusion, bFGF is the major angiogenic factor expressed in ovarian carcinoma at the mRNA level.
TextSentencer_T18 2229-2556 Sentence denotes It is highly expressed in both solid tumors and serous effusions, while IL-8 and VEGF are down regulated in carcinoma cells in effusions, possibly due to the lack of interaction with stromal cells. mRNA expression of VEGF, bFGF, and IL-8 does not appear to be a predictor of disease outcome in advanced-stage ovarian carcinoma.
T18 2229-2556 Sentence denotes It is highly expressed in both solid tumors and serous effusions, while IL-8 and VEGF are down regulated in carcinoma cells in effusions, possibly due to the lack of interaction with stromal cells. mRNA expression of VEGF, bFGF, and IL-8 does not appear to be a predictor of disease outcome in advanced-stage ovarian carcinoma.
TextSentencer_T19 2557-2772 Sentence denotes Carcinoma cells in pleural and peritoneal effusions show a similar metastatic expression profile, in agreement with our previous findings, supporting the true metastatic nature of ovarian carcinoma cells in ascites.
T19 2557-2772 Sentence denotes Carcinoma cells in pleural and peritoneal effusions show a similar metastatic expression profile, in agreement with our previous findings, supporting the true metastatic nature of ovarian carcinoma cells in ascites.