| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-58 |
Sentence |
denotes |
Structural determinants of BRCA1 translational regulation. |
| T2 |
59-158 |
Sentence |
denotes |
The BRCA1 gene is involved in sporadic breast and ovarian cancer mainly through reduced expression. |
| T3 |
159-247 |
Sentence |
denotes |
BRCA1 mRNAs containing different leader sequences show different patterns of expression. |
| T4 |
248-423 |
Sentence |
denotes |
In a normal mammary gland mRNA with a shorter leader sequence, 5'-UTRa is expressed only, whereas in breast cancer tissue mRNA with a longer leader, 5'-UTRb is expressed also. |
| T5 |
424-546 |
Sentence |
denotes |
We show that the translation efficiency of transcripts containing 5'-UTRb is 10 times lower than those containing 5'-UTRa. |
| T6 |
547-726 |
Sentence |
denotes |
The structures of 5'-UTRa and 5'-UTRb were determined by chemical and enzymatic probing aided by a new method developed for monitoring the number of co-existing stable conformers. |
| T7 |
727-892 |
Sentence |
denotes |
Specific factors responsible for reduced translation of mRNA containing 5'-UTRb were determined using a variety of transcripts with mutations in the leader sequence. |
| T8 |
893-1000 |
Sentence |
denotes |
These factors include a stable secondary structure formed by truncated Alu element and upstream AUG codons. |
| T9 |
1001-1102 |
Sentence |
denotes |
The novel mechanism by which BRCA1 may be involved in sporadic breast and ovarian cancer is proposed. |
| T10 |
1103-1198 |
Sentence |
denotes |
It is based on the expression patterns of BRCA1 mRNAs and differences in their translatability. |
| T11 |
1199-1473 |
Sentence |
denotes |
According to this mechanism the deregulation of the BRCA1 transcription in cancer, resulting in a higher proportion of translationally inhibited transcripts containing 5'-UTRb, contributes to the decrease in the BRCA1 protein observed in sporadic breast and ovarian cancers. |
