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PubMed:11844822 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-96 Sentence denotes BRCA1 and BRCA2 mutation frequency in women evaluated in a breast cancer risk evaluation clinic.
T1 0-96 Sentence denotes BRCA1 and BRCA2 mutation frequency in women evaluated in a breast cancer risk evaluation clinic.
TextSentencer_T2 97-105 Sentence denotes PURPOSE:
T2 97-105 Sentence denotes PURPOSE:
TextSentencer_T3 106-228 Sentence denotes To determine the prevalence of BRCA1 and BRCA2 mutations in families identified in a breast cancer risk evaluation clinic.
T3 106-228 Sentence denotes To determine the prevalence of BRCA1 and BRCA2 mutations in families identified in a breast cancer risk evaluation clinic.
TextSentencer_T4 229-250 Sentence denotes PATIENTS AND METHODS:
T4 229-250 Sentence denotes PATIENTS AND METHODS:
TextSentencer_T5 251-447 Sentence denotes One hundred sixty-four families seeking breast cancer risk evaluation were screened for coding region mutations in BRCA1 and BRCA2 by conformation-sensitive gel electrophoresis and DNA sequencing.
T5 251-447 Sentence denotes One hundred sixty-four families seeking breast cancer risk evaluation were screened for coding region mutations in BRCA1 and BRCA2 by conformation-sensitive gel electrophoresis and DNA sequencing.
TextSentencer_T6 448-456 Sentence denotes RESULTS:
T6 448-456 Sentence denotes RESULTS:
TextSentencer_T7 457-574 Sentence denotes Mutations were identified in 37 families (22.6%); 28 (17.1%) had BRCA1 mutations and nine (5.5%) had BRCA2 mutations.
T7 457-574 Sentence denotes Mutations were identified in 37 families (22.6%); 28 (17.1%) had BRCA1 mutations and nine (5.5%) had BRCA2 mutations.
TextSentencer_T8 575-677 Sentence denotes The Ashkenazi Jewish founder mutations 185delAG and 5382insC (BRCA1) were found in 10 families (6.1%).
T8 575-677 Sentence denotes The Ashkenazi Jewish founder mutations 185delAG and 5382insC (BRCA1) were found in 10 families (6.1%).
TextSentencer_T9 678-805 Sentence denotes However, 6174delT (BRCA2) was found in only one family (0.6%) despite estimates of equal frequency in the Ashkenazi population.
T9 678-805 Sentence denotes However, 6174delT (BRCA2) was found in only one family (0.6%) despite estimates of equal frequency in the Ashkenazi population.
TextSentencer_T10 806-987 Sentence denotes In contrast to other series, the average age of breast cancer diagnosis was earlier in BRCA2 mutation carriers (32.1 years) than in women with BRCA1 mutations (37.6 years, P =.028).
T10 806-987 Sentence denotes In contrast to other series, the average age of breast cancer diagnosis was earlier in BRCA2 mutation carriers (32.1 years) than in women with BRCA1 mutations (37.6 years, P =.028).
TextSentencer_T11 988-1154 Sentence denotes BRCA1 mutations were detected in 20 (45.5%) of 44 families with ovarian cancer and 12 (75%) of 16 families with both breast and ovarian cancer in a single individual.
T11 988-1154 Sentence denotes BRCA1 mutations were detected in 20 (45.5%) of 44 families with ovarian cancer and 12 (75%) of 16 families with both breast and ovarian cancer in a single individual.
TextSentencer_T12 1155-1265 Sentence denotes Significantly fewer BRCA2 mutations (two [4.5%] of 44) were detected in families with ovarian cancer (P =.01).
T12 1155-1265 Sentence denotes Significantly fewer BRCA2 mutations (two [4.5%] of 44) were detected in families with ovarian cancer (P =.01).
TextSentencer_T13 1266-1360 Sentence denotes Eight families had male breast cancer; one had a BRCA1 mutation and three had BRCA2 mutations.
T13 1266-1360 Sentence denotes Eight families had male breast cancer; one had a BRCA1 mutation and three had BRCA2 mutations.
TextSentencer_T14 1361-1442 Sentence denotes CONCLUSION: BRCA1 mutations were three times more prevalent than BRCA2 mutations.
T14 1361-1442 Sentence denotes CONCLUSION: BRCA1 mutations were three times more prevalent than BRCA2 mutations.
TextSentencer_T15 1443-1733 Sentence denotes Breast cancer diagnosis before 50 years of age, ovarian cancer, breast and ovarian cancer in a single individual, and male breast cancer were all significantly more common in families with BRCA1 and BRCA2 mutations, but none of these factors distinguished between BRCA1 and BRCA2 mutations.
T15 1443-1733 Sentence denotes Breast cancer diagnosis before 50 years of age, ovarian cancer, breast and ovarian cancer in a single individual, and male breast cancer were all significantly more common in families with BRCA1 and BRCA2 mutations, but none of these factors distinguished between BRCA1 and BRCA2 mutations.
TextSentencer_T16 1734-1834 Sentence denotes Evidence for reduced breast cancer penetrance associated with the BRCA2 mutation 6174delT was noted.
T16 1734-1834 Sentence denotes Evidence for reduced breast cancer penetrance associated with the BRCA2 mutation 6174delT was noted.