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PubMed:11815617 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing.
T2 120-275 Sentence denotes Apolipoprotein B (apoB) mRNA editing involves site-specific deamination of cytidine to form uridine, resulting in the production of an in-frame stop codon.
T3 276-452 Sentence denotes Protein translated from edited mRNA is associated with a reduced risk of atherosclerosis, and hence the protein factors that regulate hepatic apoB mRNA editing are of interest.
T4 453-587 Sentence denotes A human protein essential for apoB mRNA editing and an eight-amino acid-longer variant of no known function have been recently cloned.
T5 588-758 Sentence denotes We report that both proteins, henceforth referred to as ACF64 and ACF65, supported APOBEC-1 (the catalytic subunit of the editosome) equivalently in editing of apoB mRNA.
T6 759-816 Sentence denotes They are encoded by a single 82-kb gene on chromosome 10.
T7 817-961 Sentence denotes The transcripts are encoded by 15 exons that are expressed from a tissue-specific promoter minimally contained within the -0.33-kb DNA sequence.
T8 962-1061 Sentence denotes ACF64 and ACF65 mRNAs are expressed in both liver and intestinal cells in an approximate 1:4 ratio.
T9 1062-1191 Sentence denotes Exon 11 is alternatively spliced to include or exclude 24 nucleotides of exon 12, thereby encoding ACF65 and ACF64, respectively.
T10 1192-1349 Sentence denotes Recognition motifs for the serine/arginine-rich (SR) proteins SC35, SRp40, SRp55, and SF2/ASF involved in alternative RNA splicing were predicted in exon 12.
T11 1350-1519 Sentence denotes Overexpression of these SR proteins in liver cells demonstrated that alternative splicing of a minigene-derived transcript to express ACF65 was enhanced 6-fold by SRp40.
T12 1520-1655 Sentence denotes The data account for the expression of two editing factors and provide a possible explanation for their different levels of expression.