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PubMed:11773079 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
T2 86-265 Sentence denotes Signal transducer and activator of transcription 3 (STAT3) transcription factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation.
T3 266-390 Sentence denotes Following tyrosine phosphorylation, STAT3 proteins dimerize, translocate to the nucleus, and activate specific target genes.
T4 391-539 Sentence denotes This transcriptional activation by STAT3 proteins has been shown to require the recruitment of coactivators such as CREB-binding protein (CBP)/p300.
T5 540-726 Sentence denotes In the present study, we show that steroid receptor coactivator 1, NcoA/SRC1a, originally identified as a nuclear receptor coactivator, also functions as a coactivator of STAT3 proteins.
T6 727-850 Sentence denotes In coimmunoprecipitations, NcoA/SRC1a was found to associate with STAT3 following IL-6 stimulation of HepG2 hepatoma cells.
T7 851-969 Sentence denotes Pull-down experiments indicated that the N-terminal part of NcoA/SRC1a associates with the activation domain of STAT3.
T8 970-1112 Sentence denotes Overexpression of NcoA/SRC1a or its SRC1e isoform enhanced transcriptional activation by STAT3 proteins in transient transfection experiments.
T9 1113-1248 Sentence denotes This ability of NcoA/SRC1a to enhance STAT3 activity is dependent upon the presence of the CBP-interacting domain, activation domain 1.
T10 1249-1430 Sentence denotes Using chromatin immunoprecipitation assays, we found that STAT3, NcoA/SRC1a, and CBP/p300 are simultaneously recruited to the p21(waf1) promoter following interleukin-6 stimulation.
T11 1431-1571 Sentence denotes Taken together, these data suggest that CBP/p300 and NcoA/SRC1a may function in a common pathway to regulate STAT3 transcriptional activity.