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PubMed:11741979 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase.
T2 83-144 Sentence denotes Its functional implication in endothelial cell proliferation.
T3 145-296 Sentence denotes Human p43 is associated with macromolecular tRNA synthase complex and known as a precursor of endothelial monocyte-activating polypeptide II (EMAP II).
T4 297-365 Sentence denotes Interestingly, p43 is also secreted to induce proinflammatory genes.
T5 366-536 Sentence denotes Although p43 itself seems to be a cytokine working at physiological conditions, most of the functional studies have been obtained with its C-terminal equivalent, EMAP II.
T6 537-669 Sentence denotes To gain an insight into the working mechanism of p43/EMAP II, we used EMAP II and searched for an interacting cell surface molecule.
T7 670-768 Sentence denotes The level of EMAP II-binding molecule(s) was significantly increased in serum-starved tumor cells.
T8 769-865 Sentence denotes Thus, the EMAP II-binding molecule was isolated from the membrane of the serum-starved CEM cell.
T9 866-942 Sentence denotes The isolated protein was determined to be the alpha subunit of ATP synthase.
T10 943-1152 Sentence denotes The interaction of EMAP II and alpha-ATP synthase was confirmed by enzyme-linked immunosorbent assay and in vitro pull down assays and blocked with the antibodies raised against EMAP II and alpha-ATP synthase.
T11 1153-1274 Sentence denotes The binding of EMAP II to the surface of serum-starved cells was inhibited in the presence of soluble alpha-ATP synthase.
T12 1275-1385 Sentence denotes EMAP II inhibited the growth of endothelial cells, and this effect was relieved by soluble alpha-ATP synthase.
T13 1386-1528 Sentence denotes Anti-alpha-ATP synthase antibody also showed an inhibitory effect on the proliferation of endothelial cells mimicking the activity of EMAP II.
T14 1529-1671 Sentence denotes These results suggest the potential interaction of p43/EMAP II with alpha-ATP synthase and its role in the proliferation of endothelial cells.