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PubMed:11677243 JSONTXT 40 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-69 Sentence denotes Cloning and expression of human core 1 beta1,3-galactosyltransferase.
T2 70-245 Sentence denotes The common core 1 O-glycan structure Galbeta1--> 3GalNAc-R is the precursor for many extended mucin-type O-glycan structures in animal cell surface and secreted glycoproteins.
T3 246-381 Sentence denotes Core 1 is synthesized by the transfer of Gal from UDP-Gal to GalNAcalpha1-R by core 1 beta3-galactosyltransferase (core 1 beta3-Gal-T).
T4 382-461 Sentence denotes Amino acid sequences from purified rat core 1 beta3-Gal-T (Ju, T., Cummings, R.
T5 462-482 Sentence denotes D., and Canfield, W.
T6 483-495 Sentence denotes M. (2002) J.
T7 496-501 Sentence denotes Biol.
T8 502-507 Sentence denotes Chem.
T9 508-624 Sentence denotes 277, 169-177) were used to identify the core 1 beta3-Gal-T sequences in the human expressed sequence tag data bases.
T10 625-781 Sentence denotes A 1794-bp human core 1 beta3-Gal-T cDNA sequence was determined by sequencing the expressed sequence tag and performing 5'-rapid amplification of cDNA ends.
T11 782-861 Sentence denotes The core 1 beta3-Gal-T predicts a 363-amino acid type II transmembrane protein.
T12 862-1184 Sentence denotes Expression of both the full-length and epitope-tagged soluble forms of the putative enzyme in human 293T cells generated core 1 beta3-Gal-T activity that transferred galactose from UDP-Gal to GalNAcalpha1-O-phenyl, and a synthetic glycopeptide with Thr-linked GalNAc and the product was shown to have the core 1 structure.
T13 1185-1329 Sentence denotes Northern analysis demonstrated widespread expression of core 1 beta3-Gal-T in tissues with a predominance in kidney, heart, placenta, and liver.
T14 1330-1513 Sentence denotes Highly homologous cDNAs were identified and cloned from rat, mouse, Drosophila melanogaster, and Caenorhabditis elegans, suggesting that the enzyme is widely distributed in metazoans.
T15 1514-1749 Sentence denotes The core 1 beta3-Gal-T sequence has minimal homology with conserved sequences found in previously described beta3-galactosyltransferases, suggesting this enzyme is only distantly related to the known beta3-galactosyltransferase family.