| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-153 |
Sentence |
denotes |
A dinucleotide repeat polymorphism at the poly(ADP-ribose) polymerase gene is not associated with predisposition to type 1 diabetes in French Caucasians. |
| T1 |
0-153 |
Sentence |
denotes |
A dinucleotide repeat polymorphism at the poly(ADP-ribose) polymerase gene is not associated with predisposition to type 1 diabetes in French Caucasians. |
| TextSentencer_T2 |
154-255 |
Sentence |
denotes |
The poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme that detects and binds DNA strand breaks. |
| T2 |
154-255 |
Sentence |
denotes |
The poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme that detects and binds DNA strand breaks. |
| TextSentencer_T3 |
256-364 |
Sentence |
denotes |
Excessive PARP activation leads to the death of mice islet beta-cells by depleting cellular energy reserves. |
| T3 |
256-364 |
Sentence |
denotes |
Excessive PARP activation leads to the death of mice islet beta-cells by depleting cellular energy reserves. |
| TextSentencer_T4 |
365-660 |
Sentence |
denotes |
On the other hand, PARP-mutant mice are resistant to streptozotocine-induced diabetes, and in the non-obese diabetic (NOD) mouse model, treatment with nicotinamide, a PARP inhibitor, protects islet cells against cytotoxic actions in vitro and results in a decreased incidence of type 1 diabetes. |
| T4 |
365-660 |
Sentence |
denotes |
On the other hand, PARP-mutant mice are resistant to streptozotocine-induced diabetes, and in the non-obese diabetic (NOD) mouse model, treatment with nicotinamide, a PARP inhibitor, protects islet cells against cytotoxic actions in vitro and results in a decreased incidence of type 1 diabetes. |
| TextSentencer_T5 |
661-854 |
Sentence |
denotes |
PARP gene in human is located within a recently identified type 1 diabetes-susceptibility region on chromosome 1q41-42, and contains a polymorphic CA dinucleotide repeat in the promoter region. |
| T5 |
661-854 |
Sentence |
denotes |
PARP gene in human is located within a recently identified type 1 diabetes-susceptibility region on chromosome 1q41-42, and contains a polymorphic CA dinucleotide repeat in the promoter region. |
| TextSentencer_T6 |
855-1137 |
Sentence |
denotes |
To consider the putative involvement of PARP polymorphism in predisposition to type 1 diabetes, we performed genotyping for the various alleles of the CA dinucleotide repeat in 158 unrelated French Caucasian patients with type 1 diabetes and 193 ethnically-matched healthy controls. |
| T6 |
855-1137 |
Sentence |
denotes |
To consider the putative involvement of PARP polymorphism in predisposition to type 1 diabetes, we performed genotyping for the various alleles of the CA dinucleotide repeat in 158 unrelated French Caucasian patients with type 1 diabetes and 193 ethnically-matched healthy controls. |
| TextSentencer_T7 |
1138-1337 |
Sentence |
denotes |
We found no significant difference of PARP alleles distribution between patients and controls, even after stratification of the patients according to HLA class II genotype or to age at disease onset. |
| T7 |
1138-1337 |
Sentence |
denotes |
We found no significant difference of PARP alleles distribution between patients and controls, even after stratification of the patients according to HLA class II genotype or to age at disease onset. |
| TextSentencer_T8 |
1338-1460 |
Sentence |
denotes |
Our results suggest that this PARP polymorphism does not influence susceptibility to type 1 diabetes in French Caucasians. |
| T8 |
1338-1460 |
Sentence |
denotes |
Our results suggest that this PARP polymorphism does not influence susceptibility to type 1 diabetes in French Caucasians. |
