| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-91 |
Sentence |
denotes |
Characterization of the human beta -glucan receptor and its alternatively spliced isoforms. |
| T2 |
92-186 |
Sentence |
denotes |
beta-1,3-d-Glucans are biological response modifiers with potent effects on the immune system. |
| T3 |
187-348 |
Sentence |
denotes |
A number of receptors are thought to play a role in mediating these responses, including murine Dectin-1, which we recently identified as a beta-glucan receptor. |
| T4 |
349-516 |
Sentence |
denotes |
In this study we describe the characterization of the human homologue of this receptor and show that it is structurally and functionally similar to the mouse receptor. |
| T5 |
517-716 |
Sentence |
denotes |
The human beta-glucan receptor is a type II transmembrane receptor with a single extracellular carbohydrate recognition domain and an immunoreceptor tyrosine activation motif in its cytoplasmic tail. |
| T6 |
717-907 |
Sentence |
denotes |
The human beta-glucan receptor is widely expressed and functions as a pattern recognition receptor, recognizing a variety of beta-1,3- and/or beta-1,6-linked glucans as well as intact yeast. |
| T7 |
908-1050 |
Sentence |
denotes |
In contrast to the murine receptor, the human receptor mRNA is alternatively spliced, resulting in two major (A and B) and six minor isoforms. |
| T8 |
1051-1262 |
Sentence |
denotes |
The two major isoforms differ by the presence of a stalk region separating the carbohydrate recognition domain from the transmembrane region and are the only isoforms that are functional for beta-glucan binding. |
| T9 |
1263-1443 |
Sentence |
denotes |
The human receptor also binds T-lymphocytes at a site distinct from the beta-glucan binding site, indicating that this receptor can recognize both endogenous and exogenous ligands. |
