| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-184 |
Sentence |
denotes |
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6). |
| T2 |
185-416 |
Sentence |
denotes |
A family of five beta1,3-galactosyltransferases has been characterized that catalyze the formation of Galbeta1,3GlcNAcbeta and Galbeta1,3GalNAcbeta linkages present in glycoproteins and glycolipids (beta3GalT1, -2, -3, -4, and -5). |
| T3 |
417-515 |
Sentence |
denotes |
We now report a new member of the family (beta3GalT6), involved in glycosaminoglycan biosynthesis. |
| T4 |
516-677 |
Sentence |
denotes |
The human and mouse genes were located on chromosomes 1p36.3 and 4E2, respectively, and homologs are found in Drosophila melanogaster and Caenorhabditis elegans. |
| T5 |
678-790 |
Sentence |
denotes |
Unlike other members of the family, beta3GalT6 showed a broad mRNA expression pattern by Northern blot analysis. |
| T6 |
791-1008 |
Sentence |
denotes |
Although a high degree of homology across several subdomains exists among other members of the beta3-galactosyltransferase family, recombinant enzyme did not utilize glucosamine- or galactosamine-containing acceptors. |
| T7 |
1009-1135 |
Sentence |
denotes |
Instead, the enzyme transferred galactose from UDP-galactose to acceptors containing a terminal beta-linked galactose residue. |
| T8 |
1136-1402 |
Sentence |
denotes |
This product, Galbeta1,3Galbeta is found in the linkage region of heparan sulfate and chondroitin sulfate (GlcAbeta1,3Galbeta1,3Galbeta1,4Xylbeta-O-Ser), indicating that beta3GalT6 is the so-called galactosyltransferase II involved in glycosaminoglycan biosynthesis. |
| T9 |
1403-1515 |
Sentence |
denotes |
Its identity was confirmed in vivo by siRNA-mediated inhibition of glycosaminoglycan synthesis in HeLa S3 cells. |
| T10 |
1516-1626 |
Sentence |
denotes |
Its localization in the medial Golgi indicates that this is the major site for assembly of the linkage region. |
