| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-67 |
Sentence |
denotes |
Hormone-mediated dephosphorylation of specific histone H1 isoforms. |
| T2 |
68-243 |
Sentence |
denotes |
We have previously shown a connection between histone H1 phosphorylation and the transcriptional competence of the hormone inducible mouse mammary tumor virus (MMTV) promoter. |
| T3 |
244-449 |
Sentence |
denotes |
Prolonged exposure of mouse cells to dexamethasone concurrently dephosphorylated histone H1 and rendered the MMTV promoter refractory to hormonal stimulation and, therefore, transcriptionally unresponsive. |
| T4 |
450-625 |
Sentence |
denotes |
Using electrospray mass spectrometry, we demonstrate here that prolonged dexamethasone treatment differentially effects a subset of the six somatic H1 isoforms in mouse cells. |
| T5 |
626-794 |
Sentence |
denotes |
H1 isoforms H1.0, H1.1, and H1.2 are non-responsive to hormone whereas prolonged dexamethasone treatment effectively dephosphorylated the H1.3, H1.4, and H1.5 isoforms. |
| T6 |
795-977 |
Sentence |
denotes |
The protein kinase inhibitor staurosporine, shown to dephosphorylate histone H1 and down-regulate MMTV in cultured cells, appears only to completely dephosphorylate the H1.3 isoform. |
| T7 |
978-1203 |
Sentence |
denotes |
These results suggest that dephosphorylation of specific histone H1 isoforms may contribute to the previously observed decrease in transcriptional competence of the MMTV promoter through the modulation of chromatin structure. |
| T8 |
1204-1409 |
Sentence |
denotes |
In a broader sense, this work advances the hypothesis that post-translational modifications of individual histone H1 isoforms directly influence the transcriptional activation/repression of specific genes. |
