| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-154 |
Sentence |
denotes |
An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form. |
| T2 |
155-270 |
Sentence |
denotes |
The LHX3 LIM homeodomain transcription factor is required for pituitary development and motor neuron specification. |
| T3 |
271-370 |
Sentence |
denotes |
The Lhx3 gene encodes two isoforms, LHX3a and LHX3b, that differ in their amino-terminal sequences. |
| T4 |
371-499 |
Sentence |
denotes |
Humans and mice with defective Lhx3 genes are deficient in gonadotrope, lactotrope, somatotrope, and thyrotrope pituitary cells. |
| T5 |
500-701 |
Sentence |
denotes |
We show that, whereas Lhx3b is highly expressed in these Lhx3-dependent cell types, high levels of Lhx3a expression are restricted to alpha glycoprotein subunit-expressing thyrotropes and gonadotropes. |
| T6 |
702-810 |
Sentence |
denotes |
Cross-species comparison reveals the LHX3b-specific domain is more conserved than the LHX3a-specific domain. |
| T7 |
811-954 |
Sentence |
denotes |
We demonstrate that the LHX3b-specific domain is a transferable inhibitor that reduces gene activation and DNA binding by homeodomain proteins. |
| T8 |
955-1101 |
Sentence |
denotes |
In addition, we identify a novel LHX3 protein (M2-LHX3) and determine that this molecule is generated by an internal translation initiation codon. |
| T9 |
1102-1206 |
Sentence |
denotes |
The LHX3a- and LHX3b-specific coding sequences regulate differential usage of this internal start codon. |
| T10 |
1207-1305 |
Sentence |
denotes |
Further, we identify the major activation domain of LHX3 in the carboxyl terminus of the molecule. |
| T11 |
1306-1396 |
Sentence |
denotes |
M2-LHX3 is active because it retains this domain and binds DNA better than LHX3a or LHX3b. |
| T12 |
1397-1478 |
Sentence |
denotes |
Other LIM homeodomain genes, including Lhx4, generate similar truncated proteins. |
| T13 |
1479-1581 |
Sentence |
denotes |
These studies describe how transcriptional regulatory genes can generate multiple functional proteins. |
