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PubMed:11445552 JSONTXT 52 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-106 Sentence denotes Sulfatide promotes the folding of proinsulin, preserves insulin crystals, and mediates its monomerization.
T1 0-106 Sentence denotes Sulfatide promotes the folding of proinsulin, preserves insulin crystals, and mediates its monomerization.
T1 0-106 Sentence denotes Sulfatide promotes the folding of proinsulin, preserves insulin crystals, and mediates its monomerization.
TextSentencer_T2 107-199 Sentence denotes Sulfatide is a glycolipid that has been associated with insulin-dependent diabetes mellitus.
T2 107-199 Sentence denotes Sulfatide is a glycolipid that has been associated with insulin-dependent diabetes mellitus.
T2 107-199 Sentence denotes Sulfatide is a glycolipid that has been associated with insulin-dependent diabetes mellitus.
TextSentencer_T3 200-294 Sentence denotes It is present in the islets of Langerhans and follows the same intracellular route as insulin.
T3 200-294 Sentence denotes It is present in the islets of Langerhans and follows the same intracellular route as insulin.
T3 200-294 Sentence denotes It is present in the islets of Langerhans and follows the same intracellular route as insulin.
TextSentencer_T4 295-360 Sentence denotes However, the role of sulfatide in the beta cell has been unclear.
T4 295-360 Sentence denotes However, the role of sulfatide in the beta cell has been unclear.
T4 295-360 Sentence denotes However, the role of sulfatide in the beta cell has been unclear.
TextSentencer_T5 361-521 Sentence denotes Here we present evidence suggesting that sulfatide promotes the folding of reduced proinsulin, indicating that sulfatide possesses molecular chaperone activity.
T5 361-521 Sentence denotes Here we present evidence suggesting that sulfatide promotes the folding of reduced proinsulin, indicating that sulfatide possesses molecular chaperone activity.
T5 361-521 Sentence denotes Here we present evidence suggesting that sulfatide promotes the folding of reduced proinsulin, indicating that sulfatide possesses molecular chaperone activity.
TextSentencer_T6 522-710 Sentence denotes Sulfatide associates with insulin by binding to the insulin domain A8--A10 and most likely by interacting with the hydrophobic side chains of the dimer-forming part of the insulin B-chain.
T6 522-710 Sentence denotes Sulfatide associates with insulin by binding to the insulin domain A8--A10 and most likely by interacting with the hydrophobic side chains of the dimer-forming part of the insulin B-chain.
T6 522-710 Sentence denotes Sulfatide associates with insulin by binding to the insulin domain A8--A10 and most likely by interacting with the hydrophobic side chains of the dimer-forming part of the insulin B-chain.
TextSentencer_T7 711-750 Sentence denotes Sulfatide has a dual effect on insulin.
T7 711-750 Sentence denotes Sulfatide has a dual effect on insulin.
T7 711-750 Sentence denotes Sulfatide has a dual effect on insulin.
TextSentencer_T8 751-892 Sentence denotes It substantially reduces deterioration of insulin hexamer crystals at pH 5.5, conferring stability comparable to those in beta cell granules.
T8 751-892 Sentence denotes It substantially reduces deterioration of insulin hexamer crystals at pH 5.5, conferring stability comparable to those in beta cell granules.
T8 751-892 Sentence denotes It substantially reduces deterioration of insulin hexamer crystals at pH 5.5, conferring stability comparable to those in beta cell granules.
TextSentencer_T9 893-1033 Sentence denotes Sulfatide also mediates the conversion of insulin hexamers to the biological active monomers at neutral pH, the pH at the beta-cell surface.
T9 893-1033 Sentence denotes Sulfatide also mediates the conversion of insulin hexamers to the biological active monomers at neutral pH, the pH at the beta-cell surface.
T9 893-1033 Sentence denotes Sulfatide also mediates the conversion of insulin hexamers to the biological active monomers at neutral pH, the pH at the beta-cell surface.
TextSentencer_T10 1034-1184 Sentence denotes Finally, we report that inhibition of sulfatide synthesis with chloroquine and fumonisine B1 leads to inhibition of insulin granule formation in vivo.
T10 1034-1184 Sentence denotes Finally, we report that inhibition of sulfatide synthesis with chloroquine and fumonisine B1 leads to inhibition of insulin granule formation in vivo.
T10 1034-1184 Sentence denotes Finally, we report that inhibition of sulfatide synthesis with chloroquine and fumonisine B1 leads to inhibition of insulin granule formation in vivo.
TextSentencer_T11 1185-1347 Sentence denotes Our observations suggest that sulfatide plays a key role in the folding of proinsulin, in the maintenance of insulin structure, and in the monomerization process.
T11 1185-1347 Sentence denotes Our observations suggest that sulfatide plays a key role in the folding of proinsulin, in the maintenance of insulin structure, and in the monomerization process.
T11 1185-1347 Sentence denotes Our observations suggest that sulfatide plays a key role in the folding of proinsulin, in the maintenance of insulin structure, and in the monomerization process.