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PubMed:11396184 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-133 Sentence denotes Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.
T1 0-133 Sentence denotes Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.
TextSentencer_T2 134-341 Sentence denotes Mutational inactivation of the human tumour suppressor gene adenomatous polyposis coli (APC) results in constitutive activation of beta-catenin/T cell factor-4 (Tcf-4) mediated transcription of target genes.
T2 134-341 Sentence denotes Mutational inactivation of the human tumour suppressor gene adenomatous polyposis coli (APC) results in constitutive activation of beta-catenin/T cell factor-4 (Tcf-4) mediated transcription of target genes.
TextSentencer_T3 342-445 Sentence denotes Up-regulation of cyclooxygenase-2 (COX-2) protein is frequently found in human colorectal cancer (CRC).
T3 342-445 Sentence denotes Up-regulation of cyclooxygenase-2 (COX-2) protein is frequently found in human colorectal cancer (CRC).
TextSentencer_T4 446-576 Sentence denotes We analysed 38 CRC for mutations in APC and beta-catenin and found an association between APC mutations and elevated COX-2 levels.
T4 446-576 Sentence denotes We analysed 38 CRC for mutations in APC and beta-catenin and found an association between APC mutations and elevated COX-2 levels.
TextSentencer_T5 577-704 Sentence denotes Furthermore, APC mutations were predominantly observed in tumour tissues from the rectum compared to tumours of colonic origin.
T5 577-704 Sentence denotes Furthermore, APC mutations were predominantly observed in tumour tissues from the rectum compared to tumours of colonic origin.
TextSentencer_T6 705-860 Sentence denotes Western blot analysis revealed that nuclear beta-catenin levels were generally higher in tumours with APC mutations compared to tumours with wild type APC.
T6 705-860 Sentence denotes Western blot analysis revealed that nuclear beta-catenin levels were generally higher in tumours with APC mutations compared to tumours with wild type APC.
TextSentencer_T7 861-1070 Sentence denotes However, there was also a higher level of nuclear beta-catenin in tumour compared to normal tissue, but nuclear Tcf-4 protein was constitutively expressed in tumour and normal tissue and showed no differences.
T7 861-1070 Sentence denotes However, there was also a higher level of nuclear beta-catenin in tumour compared to normal tissue, but nuclear Tcf-4 protein was constitutively expressed in tumour and normal tissue and showed no differences.
TextSentencer_T8 1071-1282 Sentence denotes An identified putative Tcf-4 binding element in the COX-2 promoter may partly explain the enhanced level of COX-2 and support the idea that COX-2 may be a downstream target of the APC/beta-catenin/Tcf-4 pathway.
T8 1071-1282 Sentence denotes An identified putative Tcf-4 binding element in the COX-2 promoter may partly explain the enhanced level of COX-2 and support the idea that COX-2 may be a downstream target of the APC/beta-catenin/Tcf-4 pathway.