| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-108 |
Sentence |
denotes |
Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. |
| T2 |
109-223 |
Sentence |
denotes |
We have characterized platelet-derived growth factor (PDGF) C, a novel growth factor belonging to the PDGF family. |
| T3 |
224-491 |
Sentence |
denotes |
PDGF-C is a multidomain protein with the N-terminal region homologous to the extracellular CUB domain of neuropilin-1, and the C-terminal region consists of a growth factor domain (GFD) with homology to vascular endothelial growth factor (25%) and PDGF A-chain (23%). |
| T4 |
492-594 |
Sentence |
denotes |
A serum-sensitive cleavage site between the two domains allows release of the GFD from the CUB domain. |
| T5 |
595-835 |
Sentence |
denotes |
Competition binding and immunoprecipitation studies on cells bearing both PDGF alpha and beta receptors reveal a high affinity binding of recombinant GFD (PDGF-CC) to PDGF receptor-alpha homodimers and PDGF receptor-alpha/beta heterodimers. |
| T6 |
836-996 |
Sentence |
denotes |
PDGF-CC exhibits greater mitogenic potency than PDGF-AA and comparable or greater mitogenic activity than PDGF-AB and PDGF-BB on several mesenchymal cell types. |
| T7 |
997-1160 |
Sentence |
denotes |
Analysis of PDGF-CC in vivo in a diabetic mouse model of delayed wound healing showed that PDGF-CC significantly enhanced repair of a full-thickness skin excision. |
| T8 |
1161-1363 |
Sentence |
denotes |
Together, these studies describe a third member of the PDGF family (PDGF-C) as a potent mitogen for cells of mesenchymal origin in in vitro and in vivo systems with a binding pattern similar to PDGF-AB. |
