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PubMed:11278600 JSONTXT 41 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells.
T1 0-113 Sentence denotes Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells.
TextSentencer_T2 114-287 Sentence denotes Extracellular signal-regulated kinases (Erks), members of the mitogen-activated protein kinase superfamily, play an important role in cell proliferation and differentiation.
T2 114-287 Sentence denotes Extracellular signal-regulated kinases (Erks), members of the mitogen-activated protein kinase superfamily, play an important role in cell proliferation and differentiation.
TextSentencer_T3 288-427 Sentence denotes In this study we employed a dominant negative approach to determine the role of Erks in the regulation of human osteoblastic cell function.
T3 288-427 Sentence denotes In this study we employed a dominant negative approach to determine the role of Erks in the regulation of human osteoblastic cell function.
TextSentencer_T4 428-658 Sentence denotes Human osteoblastic cells were transduced with a pseudotyped retrovirus encoding either a mutated Erk1 protein with a dominant negative action against both Erk1 and Erk2 (Erk1DN cells) or the LacZ protein (LacZ cells) as a control.
T4 428-658 Sentence denotes Human osteoblastic cells were transduced with a pseudotyped retrovirus encoding either a mutated Erk1 protein with a dominant negative action against both Erk1 and Erk2 (Erk1DN cells) or the LacZ protein (LacZ cells) as a control.
TextSentencer_T5 659-767 Sentence denotes Both basal and growth factor-stimulated MAPK activity and cell proliferation were inhibited in Erk1DN cells.
T5 659-767 Sentence denotes Both basal and growth factor-stimulated MAPK activity and cell proliferation were inhibited in Erk1DN cells.
TextSentencer_T6 768-953 Sentence denotes Expression of Erk1DN protein suppressed both osteoblast differentiation and matrix mineralization by decreasing alkaline phosphatase activity and the deposition of bone matrix proteins.
T6 768-953 Sentence denotes Expression of Erk1DN protein suppressed both osteoblast differentiation and matrix mineralization by decreasing alkaline phosphatase activity and the deposition of bone matrix proteins.
TextSentencer_T7 954-1068 Sentence denotes Cell adhesion to collagen, osteopontin, and vitronectin was decreased in Erk1DN cells as compared with LacZ cells.
T7 954-1068 Sentence denotes Cell adhesion to collagen, osteopontin, and vitronectin was decreased in Erk1DN cells as compared with LacZ cells.
TextSentencer_T8 1069-1136 Sentence denotes Cell spreading and migration on these matrices were also inhibited.
T8 1069-1136 Sentence denotes Cell spreading and migration on these matrices were also inhibited.
TextSentencer_T9 1137-1258 Sentence denotes In Erk1DN cells, expression of alphabeta(1), alpha(v)beta(3), and alpha(v)beta(5) integrins on the surface was decreased.
T9 1137-1258 Sentence denotes In Erk1DN cells, expression of alphabeta(1), alpha(v)beta(3), and alpha(v)beta(5) integrins on the surface was decreased.
TextSentencer_T10 1259-1356 Sentence denotes Metabolic labeling indicated that the synthesis of these integrins was inhibited in Erk1DN cells.
T10 1259-1356 Sentence denotes Metabolic labeling indicated that the synthesis of these integrins was inhibited in Erk1DN cells.
TextSentencer_T11 1357-1553 Sentence denotes These data suggest that Erks are not only essential for the growth and differentiation of osteoblasts but also are important for osteoblast adhesion, spreading, migration, and integrin expression.
T11 1357-1553 Sentence denotes These data suggest that Erks are not only essential for the growth and differentiation of osteoblasts but also are important for osteoblast adhesion, spreading, migration, and integrin expression.