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PubMed:11108718 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T1 0-215 Sentence denotes Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells.
T2 216-326 Sentence denotes Vascular endothelial growth factor (VEGF) induces adhesion molecules on endothelial cells during inflammation.
T3 327-545 Sentence denotes Here we examined the mechanisms underlying VEGF-stimulated expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin in human umbilical vein endothelial cells.
T4 546-650 Sentence denotes VEGF (20 ng/ml) increased expression of ICAM-1, VCAM-1, and E-selectin mRNAs in a time-dependent manner.
T5 651-1020 Sentence denotes These effects were significantly suppressed by Flk-1/kinase-insert domain containing receptor (KDR) antagonist and by inhibitors of phospholipase C, nuclear factor (NF)-kappaB, sphingosine kinase, and protein kinase C, but they were not affected by inhibitors of mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) 1/2 or nitric-oxide synthase.
T6 1021-1262 Sentence denotes Unexpectedly, the phosphatidylinositol (PI) 3'-kinase inhibitor wortmannin enhanced both basal and VEGF-stimulated adhesion molecule expression, whereas insulin, a PI 3'-kinase activator, suppressed both basal and VEGF-stimulated expression.
T7 1263-1331 Sentence denotes Gel shift analysis revealed that VEGF stimulated NF-kappaB activity.
T8 1332-1419 Sentence denotes This effect was inhibited by phospholipase C, NF-kappaB, or protein kinase C inhibitor.
T9 1420-1537 Sentence denotes VEGF increased VCAM-1 and ICAM-1 protein levels and increased leukocyte adhesiveness in a NF-kappaB-dependent manner.
T10 1538-1756 Sentence denotes These results suggest that VEGF-stimulated expression of ICAM-1, VCAM-1, and E-selectin mRNAs was mainly through NF-kappaB activation with PI 3'-kinase-mediated suppression, but was independent of nitric oxide and MEK.
T11 1757-1904 Sentence denotes Thus, VEGF simultaneously activates two signal transduction pathways that have opposite functions in the induction of adhesion molecule expression.
T12 1905-2041 Sentence denotes The existence of parallel inverse signaling implies that the induction of adhesion molecule expression by VEGF is very finely regulated.