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PubMed:11107127 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-108 Sentence denotes Resistance to TRAIL-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
T1 0-108 Sentence denotes Resistance to TRAIL-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
TextSentencer_T2 109-120 Sentence denotes BACKGROUND:
T2 109-120 Sentence denotes BACKGROUND:
TextSentencer_T3 121-249 Sentence denotes Disruption of apoptotic pathways may be involved in tumor formation, regression, and treatment resistance of neuroblastoma (NB).
T3 121-249 Sentence denotes Disruption of apoptotic pathways may be involved in tumor formation, regression, and treatment resistance of neuroblastoma (NB).
TextSentencer_T4 250-350 Sentence denotes TNF-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in cancer cell lines.
T4 250-350 Sentence denotes TNF-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in cancer cell lines.
TextSentencer_T5 351-361 Sentence denotes PROCEDURE:
T5 351-361 Sentence denotes PROCEDURE:
TextSentencer_T6 362-535 Sentence denotes In this study we analyzed the expression and function of TRAIL, its agonistic and antagonistic receptors, and important intracellular signaling elements in 18 NB cell lines.
T6 362-535 Sentence denotes In this study we analyzed the expression and function of TRAIL, its agonistic and antagonistic receptors, and important intracellular signaling elements in 18 NB cell lines.
TextSentencer_T7 536-544 Sentence denotes RESULTS:
T7 536-544 Sentence denotes RESULTS:
TextSentencer_T8 545-651 Sentence denotes Semiquantitative RT-PCR revealed that TRAIL-R2 and TRAIL-R3 are the main TRAIL-receptors used by NB cells.
T8 545-651 Sentence denotes Semiquantitative RT-PCR revealed that TRAIL-R2 and TRAIL-R3 are the main TRAIL-receptors used by NB cells.
TextSentencer_T9 652-758 Sentence denotes Sensitivity to TRAIL-induced apoptosis did not correlate with mRNA expression of TRAIL receptors or cFLIP.
T9 652-758 Sentence denotes Sensitivity to TRAIL-induced apoptosis did not correlate with mRNA expression of TRAIL receptors or cFLIP.
TextSentencer_T10 759-846 Sentence denotes Surprisingly, caspase-8 and caspase-10 mRNA was detected in only 5 of 18 NB cell lines.
T10 759-846 Sentence denotes Surprisingly, caspase-8 and caspase-10 mRNA was detected in only 5 of 18 NB cell lines.
TextSentencer_T11 847-973 Sentence denotes Interestingly, only these five NB cell lines were susceptible to TRAIL-induced apoptosis in a time- and dose-dependent manner.
T11 847-973 Sentence denotes Interestingly, only these five NB cell lines were susceptible to TRAIL-induced apoptosis in a time- and dose-dependent manner.
TextSentencer_T12 974-986 Sentence denotes CONCLUSIONS:
T12 974-986 Sentence denotes CONCLUSIONS:
TextSentencer_T13 987-1187 Sentence denotes Treatment with 5-aza-2'-deoxycytidine restored mRNA expression of caspase-8 and -10 and TRAIL sensitivity of resistant cell lines, suggesting that gene methylation is involved in caspase inactivation.
T13 987-1187 Sentence denotes Treatment with 5-aza-2'-deoxycytidine restored mRNA expression of caspase-8 and -10 and TRAIL sensitivity of resistant cell lines, suggesting that gene methylation is involved in caspase inactivation.
TextSentencer_T14 1188-1366 Sentence denotes Since many cytotoxic drugs induce caspase-dependent apoptosis, failure to express caspase-8 and/or caspase-10 might be an important mechanism of resistance to chemotherapy in NB.
T14 1188-1366 Sentence denotes Since many cytotoxic drugs induce caspase-dependent apoptosis, failure to express caspase-8 and/or caspase-10 might be an important mechanism of resistance to chemotherapy in NB.