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PubMed:10972144 JSONTXT 36 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-192 Sentence denotes Deletion of A-antigen in a human cancer cell line is associated with reduced promoter activity of CBF/NF-Y binding region, and possibly with enhanced DNA methylation of A transferase promoter.
T1 0-192 Sentence denotes Deletion of A-antigen in a human cancer cell line is associated with reduced promoter activity of CBF/NF-Y binding region, and possibly with enhanced DNA methylation of A transferase promoter.
TextSentencer_T2 193-447 Sentence denotes Employing blood group A- and A+ clones derived from the same parental colonic cancer cell lines, we studied the molecular mechanism of deletion/reduction vs. continuous expression of A antigen in A tumors, a crucial determinant of human tumor malignancy.
T2 193-447 Sentence denotes Employing blood group A- and A+ clones derived from the same parental colonic cancer cell lines, we studied the molecular mechanism of deletion/reduction vs. continuous expression of A antigen in A tumors, a crucial determinant of human tumor malignancy.
TextSentencer_T3 448-601 Sentence denotes A- transferase mRNA level in one of the A- clones (A- SW480) was undetectable, while that in A+ SW480 was strongly detectable by semiquantitative RT-PCR.
T3 448-601 Sentence denotes A- transferase mRNA level in one of the A- clones (A- SW480) was undetectable, while that in A+ SW480 was strongly detectable by semiquantitative RT-PCR.
TextSentencer_T4 602-885 Sentence denotes Relatively lower (approximately 1/3) transcript level was detectable in another A- clone (A- HT29) in comparison to A+ HT29 by the same RT-PCR procedure, although none of these tumor cell lines showed detectable level of A transcript by Northern blotting or RNase protection methods.
T4 602-885 Sentence denotes Relatively lower (approximately 1/3) transcript level was detectable in another A- clone (A- HT29) in comparison to A+ HT29 by the same RT-PCR procedure, although none of these tumor cell lines showed detectable level of A transcript by Northern blotting or RNase protection methods.
TextSentencer_T5 886-964 Sentence denotes Therefore, subsequent studies were performed employing A- vs. A+ SW480 clones.
T5 886-964 Sentence denotes Therefore, subsequent studies were performed employing A- vs. A+ SW480 clones.
TextSentencer_T6 965-1166 Sentence denotes Deletion of A transcript in A- cells was not due to gene deletion, since Southern blot analysis showed equal presence of genomic DNA regardless of A- vs. A+ (SW480 or HT29) or B+ (KATOIII) tumor cells.
T6 965-1166 Sentence denotes Deletion of A transcript in A- cells was not due to gene deletion, since Southern blot analysis showed equal presence of genomic DNA regardless of A- vs. A+ (SW480 or HT29) or B+ (KATOIII) tumor cells.
TextSentencer_T7 1167-1277 Sentence denotes Two transcriptional control mechanisms leading to differences of A expression in SW480 cells are indicated. i.
T7 1167-1277 Sentence denotes Two transcriptional control mechanisms leading to differences of A expression in SW480 cells are indicated. i.
TextSentencer_T8 1278-1448 Sentence denotes Luciferase assay in A- and A+ SW480 cells showed that promoter activities of segments of 5' flanking sequence of ABO gene reflected transcript levels in these cell lines.
T8 1278-1448 Sentence denotes Luciferase assay in A- and A+ SW480 cells showed that promoter activities of segments of 5' flanking sequence of ABO gene reflected transcript levels in these cell lines.
TextSentencer_T9 1449-1576 Sentence denotes The enhancing activity of a 43 bp tandem repeat unit located between -3899 to -3618 was reduced in A- compared to A+ cells. ii.
T9 1449-1576 Sentence denotes The enhancing activity of a 43 bp tandem repeat unit located between -3899 to -3618 was reduced in A- compared to A+ cells. ii.
TextSentencer_T10 1577-1675 Sentence denotes Distinct differences in the pattern of CpG dinucleotide methylation were found in A- vs. A+ cells.
T10 1577-1675 Sentence denotes Distinct differences in the pattern of CpG dinucleotide methylation were found in A- vs. A+ cells.
TextSentencer_T11 1676-1805 Sentence denotes Therefore, the methylation process of A promoter DNA may be another important factor controlling A activity in SW480 tumor cells.
T11 1676-1805 Sentence denotes Therefore, the methylation process of A promoter DNA may be another important factor controlling A activity in SW480 tumor cells.
TextSentencer_T12 1806-2043 Sentence denotes Since proliferation and motility of tumor cells are associated closely with A expression, transcription control mechanism for expression of A transferase as described above may be of crucial importance in defining human tumor malignancy.
T12 1806-2043 Sentence denotes Since proliferation and motility of tumor cells are associated closely with A expression, transcription control mechanism for expression of A transferase as described above may be of crucial importance in defining human tumor malignancy.