| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-175 |
Sentence |
denotes |
The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity. |
| T2 |
176-261 |
Sentence |
denotes |
Rat synaptotagmin IV (SYT IV) is a depolarization-inducible synaptic vesicle protein. |
| T3 |
262-373 |
Sentence |
denotes |
SYT IV homozygous mutant mice are viable and have deficits in fine motor coordination and some forms of memory. |
| T4 |
374-447 |
Sentence |
denotes |
In this study, we report the identification of a human SYT IV orthologue. |
| T5 |
448-569 |
Sentence |
denotes |
The predicted amino acid sequence of the human SYT IV clone is nearly 90% identical to the rat and mouse SYT IV proteins. |
| T6 |
570-770 |
Sentence |
denotes |
In addition, human SYT IV has a characteristic serine for aspartate substitution within the first C2 domain that is conserved among Drosophila, Caenorhabditis elegans, mouse, and rat SYT IV sequences. |
| T7 |
771-983 |
Sentence |
denotes |
The human SYT IV gene maps to chromosome band 18q12.3, a region that defines a break point in the synteny with mouse chromosome 18 and has been implicated by associated markers in two human psychiatric disorders. |
| T8 |
984-1159 |
Sentence |
denotes |
In the human neuroblastoma cell line SK-N-SH, SYT IV is an immediate-early gene inducible by elevated intracellular calcium and by forskolin, an activator of adenylyl cyclase. |
| T9 |
1160-1261 |
Sentence |
denotes |
Expression of human SYT IV mRNA is restricted to brain and is not detectable in non-neuronal tissues. |
| T10 |
1262-1386 |
Sentence |
denotes |
Within brain, human SYT IV mRNA is most highly expressed in hippocampus, with lower levels present in amygdala and thalamus. |
| T11 |
1387-1485 |
Sentence |
denotes |
These results suggest a role for SYT IV in human brain function and in human neurological disease. |
