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Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes Androgen receptor interacts with a novel MYST protein, HBO1.
T2 61-219 Sentence denotes The androgen receptor (AR), a member of the nuclear receptor superfamily, plays a central role in male sexual differentiation and prostate cell proliferation.
T3 220-363 Sentence denotes Results of treating prostate cancer by androgen ablation indicate that signals mediated through AR are critical for the growth of these tumors.
T4 364-578 Sentence denotes Like other nuclear receptors, AR exerts its transcriptional function by binding to cis-elements upstream of promoters and interacting with other transcriptional factors (e.g. activators, repressors and modulators).
T5 579-708 Sentence denotes To determine the mechanism of AR-regulated transcription, we used the yeast two-hybrid system to identify AR-associated proteins.
T6 709-828 Sentence denotes One of the proteins we identified is identical to the human origin recognition complex-interacting protein termed HBO1.
T7 829-922 Sentence denotes A ligand-enhanced interaction between AR and HBO1 was further confirmed in vivo and in vitro.
T8 923-1112 Sentence denotes Immunofluorescence experiments showed that HBO1 is a nuclear protein, and Northern blot analysis revealed that it is ubiquitously expressed, with the highest levels present in human testis.
T9 1113-1256 Sentence denotes HBO1 belongs to the MYST family, which is characterized by a highly conserved C2HC zinc finger and a putative histone acetyltransferase domain.
T10 1257-1441 Sentence denotes Surprisingly, two yeast members of the MYST family, SAS2 and SAS3, have been shown to function as transcription silencers, despite the presence of the histone acetyltransferase domain.
T11 1442-1564 Sentence denotes Using a GAL4 DNA-binding domain assay, we mapped a transcriptional repression domain within the N-terminal region of HBO1.
T12 1565-1696 Sentence denotes Transient transfection experiments revealed that HBO1 specifically repressed AR-mediated transcription in both CV-1 and PC-3 cells.
T13 1697-1796 Sentence denotes These results indicate that HBO1 is a new AR-interacting protein capable of modulating AR activity.
T14 1797-1899 Sentence denotes It could play a significant role in regulating AR-dependent genes in normal and prostate cancer cells.