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PubMed:10874034 JSONTXT 42 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-32 Sentence denotes Regulation of glycogen synthase.
T1 0-32 Sentence denotes Regulation of glycogen synthase.
TextSentencer_T2 33-143 Sentence denotes Identification of residues involved in regulation by the allosteric ligand glucose-6-P and by phosphorylation.
T2 33-143 Sentence denotes Identification of residues involved in regulation by the allosteric ligand glucose-6-P and by phosphorylation.
TextSentencer_T3 144-271 Sentence denotes The major yeast glycogen synthase, Gsy2p, is inactivated by phosphorylation and activated by the allosteric ligand glucose-6-P.
T3 144-271 Sentence denotes The major yeast glycogen synthase, Gsy2p, is inactivated by phosphorylation and activated by the allosteric ligand glucose-6-P.
TextSentencer_T4 272-436 Sentence denotes From studies of recombinant proteins, the control can be accommodated by a three-state model, in which unphosphorylated enzyme has intermediate activity (state II).
T4 272-436 Sentence denotes From studies of recombinant proteins, the control can be accommodated by a three-state model, in which unphosphorylated enzyme has intermediate activity (state II).
TextSentencer_T5 437-634 Sentence denotes Glucose-6-P increased V(max)/K(m) by about 2-fold (state III), whereas phosphorylation by the cyclin-dependent protein kinase Pcl10p/Pho85p decreased V(max)/K(m) by approximately 30-fold (state I).
T5 437-634 Sentence denotes Glucose-6-P increased V(max)/K(m) by about 2-fold (state III), whereas phosphorylation by the cyclin-dependent protein kinase Pcl10p/Pho85p decreased V(max)/K(m) by approximately 30-fold (state I).
TextSentencer_T6 635-725 Sentence denotes In the presence of glucose-6-P, state III is achieved regardless of phosphorylation state.
T6 635-725 Sentence denotes In the presence of glucose-6-P, state III is achieved regardless of phosphorylation state.
TextSentencer_T7 726-901 Sentence denotes The enzyme forms complexes in solution with the yeast glycogenin Glg2p, but this interaction appears not to affect control either by glucose-6-P binding or by phosphorylation.
T7 726-901 Sentence denotes The enzyme forms complexes in solution with the yeast glycogenin Glg2p, but this interaction appears not to affect control either by glucose-6-P binding or by phosphorylation.
TextSentencer_T8 902-995 Sentence denotes Scanning mutagenesis was applied to identify residues potentially involved in ligand binding.
T8 902-995 Sentence denotes Scanning mutagenesis was applied to identify residues potentially involved in ligand binding.
TextSentencer_T9 996-1059 Sentence denotes Of 22 mutant enzymes analyzed, seven were essentially inactive.
T9 996-1059 Sentence denotes Of 22 mutant enzymes analyzed, seven were essentially inactive.
TextSentencer_T10 1060-1189 Sentence denotes Five mutant proteins were altered in their activation by glucose-6-P, and two were completely unaffected by the hexose phosphate.
T10 1060-1189 Sentence denotes Five mutant proteins were altered in their activation by glucose-6-P, and two were completely unaffected by the hexose phosphate.
TextSentencer_T11 1190-1351 Sentence denotes One of these, R586A/R588A/R591A (all three of the indicated Arg residues mutated to Ala), had wild-type activity and was normally inactivated by phosphorylation.
T11 1190-1351 Sentence denotes One of these, R586A/R588A/R591A (all three of the indicated Arg residues mutated to Ala), had wild-type activity and was normally inactivated by phosphorylation.
TextSentencer_T12 1352-1477 Sentence denotes A second mutant, R579A/R580A/R582A, had somewhat reduced V(max), but its activity was not greatly reduced by phosphorylation.
T12 1352-1477 Sentence denotes A second mutant, R579A/R580A/R582A, had somewhat reduced V(max), but its activity was not greatly reduced by phosphorylation.
TextSentencer_T13 1478-1718 Sentence denotes The Arg residues in these two mutants are restricted to a highly conserved, 13-residue segment of Gsy2p that we propose to be important for glucose-6-P binding and/or the ability of the enzyme to undergo transitions between activity states.
T13 1478-1718 Sentence denotes The Arg residues in these two mutants are restricted to a highly conserved, 13-residue segment of Gsy2p that we propose to be important for glucose-6-P binding and/or the ability of the enzyme to undergo transitions between activity states.