| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-65 |
Sentence |
denotes |
Cloning and expression of the histo-blood group Pk UDP-galactose: |
| T2 |
66-120 |
Sentence |
denotes |
Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. |
| T3 |
121-164 |
Sentence |
denotes |
Molecular genetic basis of the p phenotype. |
| T4 |
165-338 |
Sentence |
denotes |
The molecular genetic basis of the P histo-blood group system has eluded characterization despite extensive studies of the biosynthesis of the P(1), P, and P(k) glycolipids. |
| T5 |
339-526 |
Sentence |
denotes |
The main controversy has been whether a single or two distinct UDP-Gal:Galbeta1-R 4-alpha-galactosyltransferases catalyze the syntheses of the structurally related P(1) and P(k) antigens. |
| T6 |
527-574 |
Sentence |
denotes |
The P(1) polymorphism is linked to 22q11.3-ter. |
| T7 |
575-718 |
Sentence |
denotes |
Data base searches with the coding region of an alpha4GlcNAc-transferase identified a novel homologous gene at 22q13.2 designated alpha4Gal-T1. |
| T8 |
719-844 |
Sentence |
denotes |
Expression of full coding constructs of alpha4Gal-T1 in insect cells revealed it encoded P(k) but not P(1) synthase activity. |
| T9 |
845-984 |
Sentence |
denotes |
Northern analysis showed expression of the transcript correlating with P(k) synthase activity and antigen expression in human B cell lines. |
| T10 |
985-1082 |
Sentence |
denotes |
Transfection of P(k)-negative Namalwa cells with alpha4Gal-T1 resulted in strong P(k) expression. |
| T11 |
1083-1246 |
Sentence |
denotes |
A single homozygous missense mutation, M183K, was found in six Swedish individuals of the rare p phenotype, confirming that alpha4Gal-T1 represented the P(k) gene. |
| T12 |
1247-1387 |
Sentence |
denotes |
Sequence analysis of the coding region of alpha4Gal-T1 in P(1)+/- individuals did not reveal polymorphisms correlating with P(1)P(2) typing. |
