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PubMed:10713103 JSONTXT 40 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-157 Sentence denotes Targeted oncogenesis reveals a distinct tissue-specific utilization of alternative promoters of the human mineralocorticoid receptor gene in transgenic mice.
T2 158-366 Sentence denotes The human mineralocorticoid receptor (hMR) is a nuclear receptor mediating aldosterone action, whose expression is driven by two alternative promoters, P1 and P2, flanking the two first 5'-untranslated exons.
T3 367-537 Sentence denotes In vivo characterization of hMR regulatory regions was performed by targeted oncogenesis in mice using P1 or P2 directing expression of the large T antigen of SV40 (TAg).
T4 538-716 Sentence denotes While transgenic P1.TAg founders rapidly developed lethal hibernomas from brown fat, cerebral primitive neuroectodermal tumors and facial leiomyosarcomas occurred in P2.TAg mice.
T5 717-1028 Sentence denotes Quantitative analyses of mouse MR (mMR) and transgene expression indicate that P1 promoter was transcriptionally active in all MR-expressing tissues, directing strong TAg expression in testis and salivary glands, moderate in lung, brain, uterus, liver, and heart but, unlike mMR, rather low in colon and kidney.
T6 1029-1116 Sentence denotes Importantly, the renal transgene expression colocalized with mMR in the distal nephron.
T7 1117-1230 Sentence denotes In contrast, P2 promoter was approximately 10 times less potent than P1, with no activity in the brain and colon.
T8 1231-1339 Sentence denotes Several immortalized cell lines were established from both neoplastic and normal tissues of transgenic mice.
T9 1340-1528 Sentence denotes These cells exhibited differentiated characteristics and maintained MR expression, thus providing useful models for further studies exploring the widespread expression and functions of MR.
T10 1529-1705 Sentence denotes Our results demonstrate that hMR gene expression in vivo is controlled by complex regulatory mechanisms involving distinct tissue-specific utilization of alternative promoters.