| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-65 |
Sentence |
denotes |
TrkA amino acids controlling specificity for nerve growth factor. |
| T2 |
66-274 |
Sentence |
denotes |
Neurotrophins are important for the development and maintenance of the vertebrate nervous system, mediating their signal into the cell by specific interaction with tyrosine kinase receptors of the Trk family. |
| T3 |
275-483 |
Sentence |
denotes |
The extracellular portion of the Trk receptors has been previously proposed to consist of a cysteine-rich motif, a leucine-rich motif, a second cysteine-rich motif followed by two immunoglobulin-like domains. |
| T4 |
484-620 |
Sentence |
denotes |
Earlier studies have shown that a major neurotrophin-binding site in the Trk receptors resides in the second immunoglobulin-like domain. |
| T5 |
621-865 |
Sentence |
denotes |
Although the individual amino acids in TrkA involved in binding to nerve growth factor (NGF) and those in TrkC involved in binding to neurotrophin-3 have been mapped in this domain, the Trk amino acids that provide specificity remained unclear. |
| T6 |
866-1051 |
Sentence |
denotes |
In this study, a minimum set of residues in the human TrkC second immunoglobulin-like domain, which does not bind nerve growth factor (NGF), were substituted with those from human TrkA. |
| T7 |
1052-1268 |
Sentence |
denotes |
The resulting Trk variant recruited binding of NGF equivalent to TrkA, maintained neurotrophin-3 binding equivalent to TrkC, and also bound brain-derived neurotrophin, although with lower affinity compared with TrkB. |
| T8 |
1269-1401 |
Sentence |
denotes |
This implies that the amino acids in the second immunoglobulin-like domain that determine Trk specificity are distinct for each Trk. |
