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PubMed:10681541 JSONTXT 42 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-102 Sentence denotes The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.
T1 0-102 Sentence denotes The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.
TextSentencer_T2 103-220 Sentence denotes A checkpoint operating in the G(2) phase of the cell cycle prevents entry into mitosis in the presence of DNA damage.
T2 103-220 Sentence denotes A checkpoint operating in the G(2) phase of the cell cycle prevents entry into mitosis in the presence of DNA damage.
TextSentencer_T3 221-415 Sentence denotes UCN-01, a protein kinase inhibitor currently undergoing clinical trials for cancer treatment, abrogates G(2) checkpoint function and sensitizes p53-defective cancer cells to DNA-damaging agents.
T3 221-415 Sentence denotes UCN-01, a protein kinase inhibitor currently undergoing clinical trials for cancer treatment, abrogates G(2) checkpoint function and sensitizes p53-defective cancer cells to DNA-damaging agents.
TextSentencer_T4 416-565 Sentence denotes In most species, the G(2) checkpoint prevents the Cdc25 phosphatase from removing inhibitory phosphate groups from the mitosis-promoting kinase Cdc2.
T4 416-565 Sentence denotes In most species, the G(2) checkpoint prevents the Cdc25 phosphatase from removing inhibitory phosphate groups from the mitosis-promoting kinase Cdc2.
TextSentencer_T5 566-660 Sentence denotes This is accomplished by maintaining Cdc25 in a phosphorylated form that binds 14-3-3 proteins.
T5 566-660 Sentence denotes This is accomplished by maintaining Cdc25 in a phosphorylated form that binds 14-3-3 proteins.
TextSentencer_T6 661-823 Sentence denotes The checkpoint kinases, Chk1 and Cds1, are proposed to regulate the interactions between human Cdc25C and 14-3-3 proteins by phosphorylating Cdc25C on serine 216.
T6 661-823 Sentence denotes The checkpoint kinases, Chk1 and Cds1, are proposed to regulate the interactions between human Cdc25C and 14-3-3 proteins by phosphorylating Cdc25C on serine 216.
TextSentencer_T7 824-893 Sentence denotes 14-3-3 proteins, in turn, function to keep Cdc25C out of the nucleus.
T7 824-893 Sentence denotes 14-3-3 proteins, in turn, function to keep Cdc25C out of the nucleus.
TextSentencer_T8 894-1018 Sentence denotes Here we report that UCN-01 caused loss of both serine 216 phosphorylation and 14-3-3 binding to Cdc25C in DNA-damaged cells.
T8 894-1018 Sentence denotes Here we report that UCN-01 caused loss of both serine 216 phosphorylation and 14-3-3 binding to Cdc25C in DNA-damaged cells.
TextSentencer_T9 1019-1111 Sentence denotes In addition, UCN-01 potently inhibited the ability of Chk1 to phosphorylate Cdc25C in vitro.
T9 1019-1111 Sentence denotes In addition, UCN-01 potently inhibited the ability of Chk1 to phosphorylate Cdc25C in vitro.
TextSentencer_T10 1112-1253 Sentence denotes In contrast, Cds1 was refractory to inhibition by UCN-01 in vitro, and Cds1 was still phosphorylated in irradiated cells treated with UCN-01.
T10 1112-1253 Sentence denotes In contrast, Cds1 was refractory to inhibition by UCN-01 in vitro, and Cds1 was still phosphorylated in irradiated cells treated with UCN-01.
TextSentencer_T11 1254-1379 Sentence denotes Thus, neither Cds1 nor kinases upstream of Cds1, such as ataxia telangiectasia-mutated, are targets of UCN-01 action in vivo.
T11 1254-1379 Sentence denotes Thus, neither Cds1 nor kinases upstream of Cds1, such as ataxia telangiectasia-mutated, are targets of UCN-01 action in vivo.
TextSentencer_T12 1380-1516 Sentence denotes Taken together our results identify the Chk1 kinase and the Cdc25C pathway as potential targets of G(2) checkpoint abrogation by UCN-01.
T12 1380-1516 Sentence denotes Taken together our results identify the Chk1 kinase and the Cdc25C pathway as potential targets of G(2) checkpoint abrogation by UCN-01.