| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-142 |
Sentence |
denotes |
ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. |
| T2 |
143-299 |
Sentence |
denotes |
Most cancers originate as a result of aberrant gene expression in mainly glandular epithelial tissues leading to defects in epithelial cell differentiation. |
| T3 |
300-370 |
Sentence |
denotes |
The latter is governed by distinct sets of transcriptional regulators. |
| T4 |
371-532 |
Sentence |
denotes |
Here we report the characterization of epithelium-specific Ets factor, family member 3 (ESE-3), a novel member of the ESE subfamily of Ets transcription factors. |
| T5 |
533-626 |
Sentence |
denotes |
ESE-3 shows highest homology to two other epithelium restricted Ets factors, ESE-1 and ESE-2. |
| T6 |
627-817 |
Sentence |
denotes |
ESE-3, like ESE-1 and ESE-2, is exclusively expressed in a subset of epithelial cells with highest expression in glandular epithelium such as prostate, pancreas, salivary gland, and trachea. |
| T7 |
818-960 |
Sentence |
denotes |
A potential role in branching morphogenesis is suggested, since ESE-3 transactivates the c-MET promoter via three high affinity binding sites. |
| T8 |
961-1152 |
Sentence |
denotes |
Additionally, ESE-3 binding to DNA sequences in the promoters of several glandular epithelium-specific genes suggests a role for ESE-3 in later stages of glandular epithelium differentiation. |
| T9 |
1153-1343 |
Sentence |
denotes |
Although ESE-3 and ESE-1 bind with similar affinity to various Ets binding sites, ESE-3 and ESE-1 differ significantly in their ability to transactivate the promoters containing these sites. |
