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PubMed:10580645 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-139 Sentence denotes CFTR antisense phosphorothioate oligodeoxynucleotides (S-ODns) induce tracheo-bronchial mucin (TBM) mRNA expression in human airway mucosa.
T1 0-139 Sentence denotes CFTR antisense phosphorothioate oligodeoxynucleotides (S-ODns) induce tracheo-bronchial mucin (TBM) mRNA expression in human airway mucosa.
TextSentencer_T2 140-222 Sentence denotes Mucus hypersecretion is a critical component of cystic fibrosis (CF) pathogenesis.
T2 140-222 Sentence denotes Mucus hypersecretion is a critical component of cystic fibrosis (CF) pathogenesis.
TextSentencer_T3 223-399 Sentence denotes The effects of dysfunction of the cystic fibrosis transmembrane regulator (CFTR) on mucin expression were examined using the tracheo-bronchial mucin (TBM) gene as an indicator.
T3 223-399 Sentence denotes The effects of dysfunction of the cystic fibrosis transmembrane regulator (CFTR) on mucin expression were examined using the tracheo-bronchial mucin (TBM) gene as an indicator.
TextSentencer_T4 400-524 Sentence denotes TBM mRNA expression was assessed in a human bronchial epithelial cell line (HBE1) and human nasal mucosal explants in vitro.
T4 400-524 Sentence denotes TBM mRNA expression was assessed in a human bronchial epithelial cell line (HBE1) and human nasal mucosal explants in vitro.
TextSentencer_T5 525-733 Sentence denotes Antisense phosphorothioate oligodeoxynucleotides (S-ODN) to TBM suppressed baseline expression of TBM mRNA in both systems, but had no effect on glyceraldehyde phosphate dehydrogenase mRNA (GAPDH) expression.
T5 525-733 Sentence denotes Antisense phosphorothioate oligodeoxynucleotides (S-ODN) to TBM suppressed baseline expression of TBM mRNA in both systems, but had no effect on glyceraldehyde phosphate dehydrogenase mRNA (GAPDH) expression.
TextSentencer_T6 734-820 Sentence denotes Sense and missense (multiple scrambled control oligonucleotides) S-ODNs had no effect.
T6 734-820 Sentence denotes Sense and missense (multiple scrambled control oligonucleotides) S-ODNs had no effect.
TextSentencer_T7 821-882 Sentence denotes 8Br-cAMP and PGE1 significantly elevated TBM mRNA expression.
T7 821-882 Sentence denotes 8Br-cAMP and PGE1 significantly elevated TBM mRNA expression.
TextSentencer_T8 883-956 Sentence denotes These increases were also specifically inhibited by the antisense S-ODNs.
T8 883-956 Sentence denotes These increases were also specifically inhibited by the antisense S-ODNs.
TextSentencer_T9 957-1030 Sentence denotes In order to induce a CF-like state, S-ODN to CFTR were added to explants.
T9 957-1030 Sentence denotes In order to induce a CF-like state, S-ODN to CFTR were added to explants.
TextSentencer_T10 1031-1152 Sentence denotes Antisense CFTR S-ODNs were anticipated to reduce the expression of cellular CFTR protein, and the level of CFTR function.
T10 1031-1152 Sentence denotes Antisense CFTR S-ODNs were anticipated to reduce the expression of cellular CFTR protein, and the level of CFTR function.
TextSentencer_T11 1153-1246 Sentence denotes Antisense, but not sense or missense, CFTR S-ODN significantly increased TBM mRNA expression.
T11 1153-1246 Sentence denotes Antisense, but not sense or missense, CFTR S-ODN significantly increased TBM mRNA expression.
TextSentencer_T12 1247-1421 Sentence denotes These data suggest that mucin hypersecretion in CF may be a direct consequence of CFTR dysfunction; the specific mechanism through which this effect is mediated is not known.
T12 1247-1421 Sentence denotes These data suggest that mucin hypersecretion in CF may be a direct consequence of CFTR dysfunction; the specific mechanism through which this effect is mediated is not known.