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PubMed:10496602 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-117 Sentence denotes Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors.
T1 0-117 Sentence denotes Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors.
TextSentencer_T2 118-281 Sentence denotes Multiple endocrine neoplasia type 1 (MEN1) is characterized by the development of endocrine tumors of the parathyroid and pituitary glands, pancreas, and duodenum.
T2 118-281 Sentence denotes Multiple endocrine neoplasia type 1 (MEN1) is characterized by the development of endocrine tumors of the parathyroid and pituitary glands, pancreas, and duodenum.
TextSentencer_T3 282-399 Sentence denotes Less frequently occurring tumors associated with MEN1 include non-endocrine tumors such as lipomas and angiofibromas.
T3 282-399 Sentence denotes Less frequently occurring tumors associated with MEN1 include non-endocrine tumors such as lipomas and angiofibromas.
TextSentencer_T4 400-585 Sentence denotes An increased incidence of thyroid neoplasms, leiomyomas, adrenal cortical hyperplasia, hepatic focal nodular hyperplasia, and renal angiomyolipoma has been noted in the MEN1 population.
T4 400-585 Sentence denotes An increased incidence of thyroid neoplasms, leiomyomas, adrenal cortical hyperplasia, hepatic focal nodular hyperplasia, and renal angiomyolipoma has been noted in the MEN1 population.
TextSentencer_T5 586-651 Sentence denotes The pathogenesis of non-neuroendocrine tumors in MEN1 is unknown.
T5 586-651 Sentence denotes The pathogenesis of non-neuroendocrine tumors in MEN1 is unknown.
TextSentencer_T6 652-796 Sentence denotes We report a complex clinical course and a detailed morphologic and genetic analysis of a series of tumors that developed in a patient with MEN1.
T6 652-796 Sentence denotes We report a complex clinical course and a detailed morphologic and genetic analysis of a series of tumors that developed in a patient with MEN1.
TextSentencer_T7 797-885 Sentence denotes All tumors were microdissected and analyzed for loss of heterozygosity of the MEN1 gene.
T7 797-885 Sentence denotes All tumors were microdissected and analyzed for loss of heterozygosity of the MEN1 gene.
TextSentencer_T8 886-1173 Sentence denotes A germline mutation of the MEN1 gene was detected, and deletions of the MEN1 gene were consistently detected in multiple neuroendocrine tumors involving the parathyroid glands and the pancreas and a hepatic neuroendocrine tumor metastasis, as predicted by Knudson's "two hit" hypothesis.
T8 886-1173 Sentence denotes A germline mutation of the MEN1 gene was detected, and deletions of the MEN1 gene were consistently detected in multiple neuroendocrine tumors involving the parathyroid glands and the pancreas and a hepatic neuroendocrine tumor metastasis, as predicted by Knudson's "two hit" hypothesis.
TextSentencer_T9 1174-1335 Sentence denotes Two hits of the MEN1 gene were also detected in esophageal leiomyoma tissue, suggesting that tumorigenesis was directly related to the patient's underlying MEN1.
T9 1174-1335 Sentence denotes Two hits of the MEN1 gene were also detected in esophageal leiomyoma tissue, suggesting that tumorigenesis was directly related to the patient's underlying MEN1.
TextSentencer_T10 1336-1582 Sentence denotes In contrast, follicular thyroid adenoma, papillary thyroid carcinoma, hepatic focal nodular hyperplasia, and adrenal cortical hyperplasia consistently showed retained heterozygosity of the MEN1 gene with flanking markers and an intragenic marker.
T10 1336-1582 Sentence denotes In contrast, follicular thyroid adenoma, papillary thyroid carcinoma, hepatic focal nodular hyperplasia, and adrenal cortical hyperplasia consistently showed retained heterozygosity of the MEN1 gene with flanking markers and an intragenic marker.
TextSentencer_T11 1583-1710 Sentence denotes Therefore, these tumors appear to develop along pathogenetic pathways that are different from classical MEN1-associated tumors.
T11 1583-1710 Sentence denotes Therefore, these tumors appear to develop along pathogenetic pathways that are different from classical MEN1-associated tumors.