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PubMed:10488147 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3.
T2 116-267 Sentence denotes Previously, we mapped the novel CC chemokine myeloid progenitor inhibitory factor 2 (MPIF-2)/eotaxin-2 to chromosome 7q11.23 (Nomiyama, H., Osborne, L.
T3 268-362 Sentence denotes R., Imai, T., Kusuda, J., Miura, R., Tsui, L.-C., and Yoshie, O. (1998) Genomics 49, 339-340).
T4 363-497 Sentence denotes Since chemokine genes tend to be clustered, unknown chemokines may be present in the vicinity of those mapped to new chromosomal loci.
T5 498-666 Sentence denotes Prompted by this hypothesis, we analyzed the genomic region containing the gene for MPIF-2/eotaxin-2 (SCYA24) and have identified a novel CC chemokine termed eotaxin-3.
T6 667-790 Sentence denotes The genes for MPIF-2/eotaxin-2 (SCYA24) and eotaxin-3 (SCYA26) are localized within a region of approximately 40 kilobases.
T7 791-885 Sentence denotes By Northern blot analysis, eotaxin-3 mRNA was constitutively expressed in the heart and ovary.
T8 886-961 Sentence denotes We have generated recombinant eotaxin-3 in a baculovirus expression system.
T9 962-1103 Sentence denotes Eotaxin-3 induced transient calcium mobilization specifically in CC chemokine receptor 3 (CCR3)-expressing L1.2 cells with an EC(50) of 3 nM.
T10 1104-1207 Sentence denotes Eotaxin-3 competed the binding of (125)I-eotaxin to CCR3-expressing L1.2 cells with an IC(50) of 13 nM.
T11 1208-1311 Sentence denotes Eotaxin-3 was chemotactic for normal peripheral blood eosinophils and basophils at high concentrations.
T12 1312-1378 Sentence denotes Collectively, eotaxin-3 is yet another functional ligand for CCR3.
T13 1379-1491 Sentence denotes The potency of eotaxin-3 as a CCR3 ligand seems, however, to be approximately 10-fold less than that of eotaxin.
T14 1492-1645 Sentence denotes Identification of eotaxin-3 will further promote our understanding of the control of eosinophil trafficking and other CCR3-mediated biological phenomena.
T15 1646-1752 Sentence denotes The strategy used in this study may also be applicable to identification of other unknown chemokine genes.