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PubMed:10464302 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Association of the Ras to mitogen-activated protein kinase signal transduction pathway with microfilaments.
T2 108-261 Sentence denotes Evidence for a p185(neu)-containing cell surface signal transduction particle linking the mitogenic pathway to a membrane-microfilament association site.
T3 262-480 Sentence denotes Microvilli of the aggressive 13762 ascites mammary adenocarcinoma contain a large, microfilament-associated signal transduction particle whose scaffolding is a stable glycoprotein complex (Li, Y., Hua, F., Carraway, K.
T4 481-501 Sentence denotes L., and Carraway, C.
T5 502-504 Sentence denotes A.
T6 505-517 Sentence denotes C. (1999) J.
T7 518-523 Sentence denotes Biol.
T8 524-529 Sentence denotes Chem.
T9 530-601 Sentence denotes 274, 25651-25658) associated with the growth factor receptor p185(neu).
T10 602-797 Sentence denotes The receptor is constitutively tyrosine-phosphorylated in the cells and microvilli, predicting that it should recruit mitogenic pathway components to this membrane-microfilament interaction site.
T11 798-1043 Sentence denotes Immunoprecipitation of cell lysates with anti-phosphotyrosine and immunoblotting showed phosphorylated forms of the mitogenic pathway proteins Shc and MAPK in addition to p185(neu), suggesting that the Ras to MAPK mitogenic pathway is activated.
T12 1044-1363 Sentence denotes Immunoblotting of p185(neu)-containing microvillar fractions revealed the presence in each of stably associated Shc, Grb-2, Sos, Ras, Raf, mitogen-activated protein kinase kinase, and mitogen-activated protein kinase/extracellular signal-regulated kinase, as well as the transcription factor-phosphorylating kinase Rsk.
T13 1364-1526 Sentence denotes All of these pathway components co-immunoprecipitated with p185(neu) from cleared lysates of microvilli solubilized under microfilament-depolymerizing conditions.
T14 1527-1825 Sentence denotes The recruitment of constitutively phosphorylated p185(neu) and the activated mitogenic pathway proteins to this membrane-microfilament interaction site provides a physical model for integrating the assembly of the mitogenic pathway with the transmission of growth factor signal to the cytoskeleton.
T15 1826-1931 Sentence denotes This linkage is probably a requisite step in the global cytoskeleton remodeling accompanying mitogenesis.