| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-142 |
Sentence |
denotes |
The formation of the oncofetal J28 glycotope involves core-2 beta6-N-acetylglucosaminyltransferase and alpha3/4-fucosyltransferase activities. |
| T1 |
0-142 |
Sentence |
denotes |
The formation of the oncofetal J28 glycotope involves core-2 beta6-N-acetylglucosaminyltransferase and alpha3/4-fucosyltransferase activities. |
| T1 |
0-142 |
Sentence |
denotes |
The formation of the oncofetal J28 glycotope involves core-2 beta6-N-acetylglucosaminyltransferase and alpha3/4-fucosyltransferase activities. |
| TextSentencer_T2 |
143-327 |
Sentence |
denotes |
The feto-acinar pancreatic protein or FAPP, the oncofetal glycoisoform of bile salt-dependent lipase (BSDL), is characterized by the presence of the J28 glycotope recognized by mAbJ28. |
| T2 |
143-327 |
Sentence |
denotes |
The feto-acinar pancreatic protein or FAPP, the oncofetal glycoisoform of bile salt-dependent lipase (BSDL), is characterized by the presence of the J28 glycotope recognized by mAbJ28. |
| T2 |
143-327 |
Sentence |
denotes |
The feto-acinar pancreatic protein or FAPP, the oncofetal glycoisoform of bile salt-dependent lipase (BSDL), is characterized by the presence of the J28 glycotope recognized by mAbJ28. |
| TextSentencer_T3 |
328-436 |
Sentence |
denotes |
This fucosylated epitope is carried out by the O-linked glycans of the C-terminal mucin-like region of BSDL. |
| T3 |
328-436 |
Sentence |
denotes |
This fucosylated epitope is carried out by the O-linked glycans of the C-terminal mucin-like region of BSDL. |
| T3 |
328-436 |
Sentence |
denotes |
This fucosylated epitope is carried out by the O-linked glycans of the C-terminal mucin-like region of BSDL. |
| TextSentencer_T4 |
437-575 |
Sentence |
denotes |
This glycotope is expressed by human tumoral pancreatic tissues and by human pancreatic tumoral cell lines such as SOJ-6 and BxPC-3 cells. |
| T4 |
437-575 |
Sentence |
denotes |
This glycotope is expressed by human tumoral pancreatic tissues and by human pancreatic tumoral cell lines such as SOJ-6 and BxPC-3 cells. |
| T4 |
437-575 |
Sentence |
denotes |
This glycotope is expressed by human tumoral pancreatic tissues and by human pancreatic tumoral cell lines such as SOJ-6 and BxPC-3 cells. |
| TextSentencer_T5 |
576-678 |
Sentence |
denotes |
However, it is not expressed by the normal human pancreatic tissues and by MiaPaCa-2 and Panc-1 cells. |
| T5 |
576-678 |
Sentence |
denotes |
However, it is not expressed by the normal human pancreatic tissues and by MiaPaCa-2 and Panc-1 cells. |
| T5 |
576-678 |
Sentence |
denotes |
However, it is not expressed by the normal human pancreatic tissues and by MiaPaCa-2 and Panc-1 cells. |
| TextSentencer_T6 |
679-844 |
Sentence |
denotes |
Due to the presence of many putative sites for O-glycosylation on FAPP and BSDL, the structure of the J28 glycotope cannot be attained by classical physical methods. |
| T6 |
679-844 |
Sentence |
denotes |
Due to the presence of many putative sites for O-glycosylation on FAPP and BSDL, the structure of the J28 glycotope cannot be attained by classical physical methods. |
| T6 |
679-844 |
Sentence |
denotes |
Due to the presence of many putative sites for O-glycosylation on FAPP and BSDL, the structure of the J28 glycotope cannot be attained by classical physical methods. |
| TextSentencer_T7 |
845-1132 |
Sentence |
denotes |
In the first part of the present study, we have determined which glycosyltransferases were differently expressed in pancreatic tumoral cell lines compared to normal tissues, focusing in part on fucosyltransferases (Fuc-T) and core-2 beta6-N-acetylglucosaminyltransferase (Core2GlcNAc-T). |
| T7 |
845-1132 |
Sentence |
denotes |
In the first part of the present study, we have determined which glycosyltransferases were differently expressed in pancreatic tumoral cell lines compared to normal tissues, focusing in part on fucosyltransferases (Fuc-T) and core-2 beta6-N-acetylglucosaminyltransferase (Core2GlcNAc-T). |
| T7 |
845-1132 |
Sentence |
denotes |
In the first part of the present study, we have determined which glycosyltransferases were differently expressed in pancreatic tumoral cell lines compared to normal tissues, focusing in part on fucosyltransferases (Fuc-T) and core-2 beta6-N-acetylglucosaminyltransferase (Core2GlcNAc-T). |
| TextSentencer_T8 |
1133-1262 |
Sentence |
denotes |
Our data suggested that alpha2-Fuc-T activity was decreased in the four cell lines tested (SOJ-6, BxPC-3, MiaPaCa-2, and Panc-1). |
| T8 |
1133-1262 |
Sentence |
denotes |
Our data suggested that alpha2-Fuc-T activity was decreased in the four cell lines tested (SOJ-6, BxPC-3, MiaPaCa-2, and Panc-1). |
| T8 |
1133-1262 |
Sentence |
denotes |
Our data suggested that alpha2-Fuc-T activity was decreased in the four cell lines tested (SOJ-6, BxPC-3, MiaPaCa-2, and Panc-1). |
| TextSentencer_T9 |
1263-1508 |
Sentence |
denotes |
The alpha(1-3) and alpha(1-4) fucosylations were decreased in tumor cells that do not express the J28 glycotope whereas alpha4-Fuc-T and Core2GlcNAc-T activities were significantly increased in SOJ-6 cells which best expressed the J28 glycotope. |
| T9 |
1263-1508 |
Sentence |
denotes |
The alpha(1-3) and alpha(1-4) fucosylations were decreased in tumor cells that do not express the J28 glycotope whereas alpha4-Fuc-T and Core2GlcNAc-T activities were significantly increased in SOJ-6 cells which best expressed the J28 glycotope. |
| T9 |
1263-1508 |
Sentence |
denotes |
The alpha(1-3) and alpha(1-4) fucosylations were decreased in tumor cells that do not express the J28 glycotope whereas alpha4-Fuc-T and Core2GlcNAc-T activities were significantly increased in SOJ-6 cells which best expressed the J28 glycotope. |
| TextSentencer_T10 |
1509-1759 |
Sentence |
denotes |
Therefore, we wished to gain information about glycosyltransferases involved in the building of this structure by transfecting the cDNA encoding the mucin-like region of BSDL in CHO-K1 also expressing Core2GlcNAc-T and/or FUT3 and/or FUT7 activities. |
| T10 |
1509-1759 |
Sentence |
denotes |
Therefore, we wished to gain information about glycosyltransferases involved in the building of this structure by transfecting the cDNA encoding the mucin-like region of BSDL in CHO-K1 also expressing Core2GlcNAc-T and/or FUT3 and/or FUT7 activities. |
| T10 |
1509-1759 |
Sentence |
denotes |
Therefore, we wished to gain information about glycosyltransferases involved in the building of this structure by transfecting the cDNA encoding the mucin-like region of BSDL in CHO-K1 also expressing Core2GlcNAc-T and/or FUT3 and/or FUT7 activities. |
| TextSentencer_T11 |
1760-1873 |
Sentence |
denotes |
These CHO-K1 cells have been previously transfected with the cDNA encoding Core2GlcNAc-T and/or FUT3 and/or FUT7. |
| T11 |
1760-1873 |
Sentence |
denotes |
These CHO-K1 cells have been previously transfected with the cDNA encoding Core2GlcNAc-T and/or FUT3 and/or FUT7. |
| T11 |
1760-1873 |
Sentence |
denotes |
These CHO-K1 cells have been previously transfected with the cDNA encoding Core2GlcNAc-T and/or FUT3 and/or FUT7. |
| TextSentencer_T12 |
1874-2033 |
Sentence |
denotes |
Data indicated that the C-terminal peptide of BSDL (Cter) produced by those cells did not carry out the J28 glycotope unless Core2GlcNAc-T activity is present. |
| T12 |
1874-2033 |
Sentence |
denotes |
Data indicated that the C-terminal peptide of BSDL (Cter) produced by those cells did not carry out the J28 glycotope unless Core2GlcNAc-T activity is present. |
| T12 |
1874-2033 |
Sentence |
denotes |
Data indicated that the C-terminal peptide of BSDL (Cter) produced by those cells did not carry out the J28 glycotope unless Core2GlcNAc-T activity is present. |
| TextSentencer_T13 |
2034-2106 |
Sentence |
denotes |
Further transfection with FUT3 cDNA, increased the antibody recognition. |
| T13 |
2034-2106 |
Sentence |
denotes |
Further transfection with FUT3 cDNA, increased the antibody recognition. |
| T13 |
2034-2106 |
Sentence |
denotes |
Further transfection with FUT3 cDNA, increased the antibody recognition. |
| TextSentencer_T14 |
2107-2236 |
Sentence |
denotes |
Nevertheless, transfection with FUT3 or FUT7 alone did not generate the formation of the J28 glycotope on the C-terminal peptide. |
| T14 |
2107-2236 |
Sentence |
denotes |
Nevertheless, transfection with FUT3 or FUT7 alone did not generate the formation of the J28 glycotope on the C-terminal peptide. |
| T14 |
2107-2236 |
Sentence |
denotes |
Nevertheless, transfection with FUT3 or FUT7 alone did not generate the formation of the J28 glycotope on the C-terminal peptide. |
| TextSentencer_T15 |
2237-2419 |
Sentence |
denotes |
Furthermore, the Cter peptide produced by CHO-K1 cells expressing Core2GlcNAc-T was more reactive to the mAbJ28 after in vitro fucosylation with the recombinant soluble form of FUT3. |
| T15 |
2237-2419 |
Sentence |
denotes |
Furthermore, the Cter peptide produced by CHO-K1 cells expressing Core2GlcNAc-T was more reactive to the mAbJ28 after in vitro fucosylation with the recombinant soluble form of FUT3. |
| T15 |
2237-2419 |
Sentence |
denotes |
Furthermore, the Cter peptide produced by CHO-K1 cells expressing Core2GlcNAc-T was more reactive to the mAbJ28 after in vitro fucosylation with the recombinant soluble form of FUT3. |
| TextSentencer_T16 |
2420-2596 |
Sentence |
denotes |
These data suggested that the J28 glycotope encompasses structures initiated by Core2GlcNAc-T and further fucosylated by alpha3/4-Fuc-T such as FUT3, likely on GlcNAc residues. |
| T16 |
2420-2596 |
Sentence |
denotes |
These data suggested that the J28 glycotope encompasses structures initiated by Core2GlcNAc-T and further fucosylated by alpha3/4-Fuc-T such as FUT3, likely on GlcNAc residues. |
| T16 |
2420-2596 |
Sentence |
denotes |
These data suggested that the J28 glycotope encompasses structures initiated by Core2GlcNAc-T and further fucosylated by alpha3/4-Fuc-T such as FUT3, likely on GlcNAc residues. |